Registration Dossier

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1987
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Qualifier:
according to guideline
Guideline:
other: Inhouse method: A-11 devloped by CIBA and is comparable to standard guidline
Deviations:
not specified
GLP compliance:
no
Analytical monitoring:
yes
Details on sampling:
See any other information on materials and methods below.
Vehicle:
yes
Details on test solutions:
300 and 1000 mg/l
Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)
Details on test organisms:
See any other information on materials and methods below.
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Remarks on exposure duration:
None
Post exposure observation period:
See any other information on materials and methods below.
Hardness:
None
Test temperature:
23 °C
pH:
8.2 to 8.4
Dissolved oxygen:
7.2 - 8.4
Salinity:
None
Conductivity:
None
Nominal and measured concentrations:
300 and 1000 mg/l
Details on test conditions:
See any other information on materials and methods below.
Reference substance (positive control):
not specified
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
462 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC0
Effect conc.:
300 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC100
Effect conc.:
1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Details on results:
No mortality was found at 300 mg/L while all fish in 1000 mg/L dose group were dead after 4 h.
Validity criteria fulfilled:
not specified
Conclusions:
The LC50 of FAT 40278/A was determined to be 462.39 mg/L.
Executive summary:

The acute fish toxicity test was performed according to a methodology similar to OECD Guideline 203 (CIBA method A-11). Zebrafish (Danio rerio) were used in the experiment setup. Two groups of fish were tested at the 300 and 1000 mg/L concentration. No mortality was found at 300 mg/L while all fish in 1000 mg/L dose group were dead after 4 h exposure. Hence, the LC50 of FAT 40278/A in this fish acute toxicity test was determined to be 462.39 mg/L.

Description of key information

The acute fish toxicity test was performed according to a method similar to OECD Guideline 203 (CIBA method A-11). Zebrafish (Danio rerio) were used in the experiment setup. Two groups of fish were tested at the 300 and 1000 mg/L concentration. No mortality was found at 300 mg/L while all fish in 1000 mg/L dose group were died after 4 h exposire. Hence, the LC50 of FAT 40278/A in this fish acute toxicity test was determined to be 462.39 mg/L.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
462.39 mg/L

Additional information