Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24 December 2015 to 08 March 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: study according to the guideline under GLP
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Radiolabelling:
- no
- Details on study design: HPLC method:
- - Test solution: 1200 mg/L in 40/60 (v/v) methanol/water (duplicate injection).
- Reference solutions: Acetanilide in 40/60 (v/v) methanol/water
Instrument Alliance Separation Module 2695 (Waters, Milford, MA, USA)
Detector Refractive index detector 2414 (Waters)
Column Hypersil BDS-CN, 150 mm x 4.6 mm i.d., dp = 5 µm (Thermo Fisher Scientific, Waltham, MA, USA)
Column temperature 35°C ± 1°C
Mobile phase 40/60 (v/v) methanol/water
Flow 1 ml/min
Injection volume 10 µl
RI detection Sensitivity 4
Time constant 1 second
Temperature 30°C - Analytical monitoring:
- yes
- Type:
- Koc
- Value:
- < 18 dimensionless
- Type:
- log Koc
- Value:
- < 1.26 dimensionless
- Details on results (HPLC method):
- The substance is a salt and the pH was kept at 7
- Validity criteria fulfilled:
- yes
- Conclusions:
- The logKoc of the test substance is <1.26
- Executive summary:
The HPLC method was used to assess the Koc of the substance. The result was a logKoc of < 1.26.
Reference
Adsorption coefficient of the test substance
Substance |
tr,1 |
tr,2 |
mean tr |
log Koc |
Koc |
|
|
|
|
|
|
Acetanilide |
2.417 |
2.418 |
|
1.26 |
|
|
|
|
|
|
|
Test item |
1.471 |
1.470 |
1.471 |
< 1.26 |
< 1.8´101 |
|
|
|
|
|
|
Description of key information
The HPLC method was used to assess the Koc of the substance. The result was a logKoc of < 1.26.
Both components have a low logKow and the adsorption potential is therefore considered to be limited.
Key value for chemical safety assessment
- Koc at 20 °C:
- 18
Additional information
[LogKoc: 1.26]
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
