Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

In a 6 or 7-day oral gavage study, plasma steady state concentration appeared to have been reached by day 4 for both male and female rats. There was evidence that the test substance preferentially partitioned into the liver in both male and female rats. A second toxicokinetic study in male and female rats via single oral gavage or i.v. injection revealed that the terminal elimination half-life ranged from 28-38 hours in males and 21-38 hours in females. Bioavailability of the test substance decreased as the dose increased indicating saturation in absorption. The test substance did not accumulate in females, but did accumulate to a small degree in male rats following 14-day repeated oral gavage.