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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data from peer reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Safety Assessment of Alkyl Taurate Amides and Taurate Salts as Used in Cosmetics
Author:
Cosmetic Ingredient Review Expert Panel
Year:
2016
Bibliographic source:
Cosmetic Ingredient Review Expert Panel, 2016

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
Acute oral toxicity study of sodium N-methyltaurinate was performed in Rat
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium N-methyltaurinate
EC Number:
224-339-0
EC Name:
Sodium N-methyltaurinate
Cas Number:
4316-74-9
Molecular formula:
C3H8NNaO3S
IUPAC Name:
Sodium 2-(methylamino)ethane-1-sulfonate
Test material form:
solid: particulate/powder
Details on test material:
- Name of test material (as cited in study report):sodium N-methyltaurinate
- Molecular formula :C3H8NNaO3S
- Molecular weight :161.156g/mole
- Substance type:organic
- Physical state:Solid
Specific details on test material used for the study:
- Name of test material (as cited in study report):sodium N-methyltaurinate
- Molecular formula :C3H8NNaO3S
- Molecular weight :161.156g/mole
- Substance type:organic
- Physical state:No data available
-Purity:No data available
- Impurities (identity and concentrations):No data available

Test animals

Species:
rat
Strain:
Wistar
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
water
Details on oral exposure:
No data available
Doses:
4000, 4500, 4750, 5000, 6300 mg/kg
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days (or other?)No data available
- Frequency of observations and weighing:No data available
- Necropsy of survivors performed: yes
- Other examinations performed: Mortality and Gross pathology were observed
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 4 670 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality was observed
Mortality:
No mortality was observed
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
Necropsies showed unspecified changes to the intestines/ gastrointestinal tract, especially in the rats that died before the end of the experiment.
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
LD50 was considered to be >4670mg/kg body weight. When wistar rats was treated with sodium N-methyltaurinate (4316-74-9) orally.
Executive summary:

Acute oral toxicity study was done in wistar rats usingsodium N-methyltaurinate (4316-74-9).test material in dose concentration 4000, 4500, 4750, 5000, 6300 mg/kg in water given by oral route. No mortality was observed at dose 4670mg/kg bw but Necropsies showed unspecified changes to the intestines/ gastrointestinal tract, especially in the rats that died before the end of the experiment HenceLD50 was considered to be >4670mg/kgbody weight. When wistar rats was treated with sodium N-methyltaurinate (4316-74-9)orally.