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EC number: 206-840-6 | CAS number: 382-10-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Conducting a ready biodegradability study in water is considered not scientifically necessary as other fluorochemical products 3,3,3-trifluoro-2-(trifluoromethyl)propene is not be expected to undergo significant biodegradation in water.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
3,3,3-trifluoro-2-(trifluoromethyl)propene has a fluorinated structure. Basing on the assessment of the molecular structure no significant biodegradation of 3,3,3-trifluoro-2-(trifluoromethyl)propene in water is expected.
Fluorinated products are recalcitrant chemicals in respect of biodegradation. The high stability in respect of biodegradation is related to the stability of the C–F bond, which is known to be the strongest existing covalent bond (450 kJ/mol) in organic chemistry. Fluorochemical products are reported to be stable in respect to degradation by acids, bases, oxidants, reductants, photolytic processes, microbes, and metabolic processes (Schultz et al. 2003). Also the presence of three pairs of nonbonding electrons around each fluorine atom and the effective shielding of carbon by the fluorine atoms is reported as a cause preventing significant attacks to the C-F bond. (Kissa 2001).
In some conditions, evidence of biodegradation of some poly- and per-fluorinated compounds is reported in literature, but such biodegradation is incomplete and may not result in mineralization. (Parson et al., 2008)
The lack of mineralization observed is ascribed the stability of the C–F bond while the not -fluorinated functionalities present in the molecule are more easily degraded.
For polyfluoroalkyl chemicals it is reported that the observed partial biodegradability is largely owing to its non-fluorinated functionality, whose breakdown precedes the breakdown of the perfluorinated carbons, if the later occurs. (Liu & Mejia Avendaño, 2013). In contrast, perfluoroalkyl chemicals in general resist biotransformation and defluorination under natural conditions. (Liu & Mejia Avendaño, 2013). Long perfluoroalkyl chains are known to be persistent in the environment (Fromel T & Knepper TP, 2010).
Defluorination has been described as a potential mechanism of degradation of fluorinated compounds. However, although reductive defluorination is expected in theory basing on thermodynamic properties and there are examples of microbially catalyzed defluorination reactions, the mechanism has rarely been observed, probably due to the less available enzymatic systems in nature, high C-F bond strength, and the absence of structures that are susceptible to electrophilic or nucleophilic attack. (Parson et al, 2006; Liu & Mejia Avendaño, 2013).
It can be therefore reasonably expected that 3,3,3-trifluoro-2-(trifluoromethyl)propene would not fulfill the conditions of ready biodegradability under a standard OECD 301 test.
3,3,3-trifluoro-2-(trifluoromethyl)propene is considered not readily biodegradable.
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