1,3-dimethyl-1,3-diphenylurea

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

08.12-16.12.2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Key result

Water solubility:

76.42 mg/L

Conc. based on:

test mat.

Incubation duration:

3 d

Temp.:

20 °C

pH:

> 5.88 - < 5.91

Table No.4: Results of determination of test substance solubility in water by flask method

 

Day	pH of saturated solution	1^stinjection (mg/L)	2^ndinjection (mg/L)	Average of 1^stand2^ndinj. (mg/L)
1^st	5.88	76.41	76.44	76.4
2^nd	5.91	76.92	76.91	76.9
3^rd	5.90	75.95	75.91	75.9
Overall Mean				76.42
SD				0.49
RSD (%)				0.64

Conclusions:

The water solubility of the test substance, Methylcentralit, established by the flask method is 76.42 mg/L.

Executive summary:

Water solubility test was performed for the test substance, Methylcentralit. Flask method was used.

Test was performed according to the Method A.6., Water Solubility, Council Regulation (EC) No.440/2008, Published in O.J. L 142, 2008.

The water solubility of the test substance, Methylcentralit, established by the flask method is 76.42 mg/L.

Description of key information

Only one study is available.

Method A.6., Water Solubility, Council Regulation (EC) No.440/2008, Published in O.J. L 142, 2008.

GLP study.

Klimish score 1.

The water solubility of the test substance, Methylcentralit, established by the flask method is 76.42 mg/L.

Key value for chemical safety assessment

Water solubility:

76.42 mg/L

at the temperature of:

20 °C