Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 914-468-7 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1970
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: basic data given, comparable to guidelines
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- unclear if limit test (only highest administrable dose stated)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Reaction mass of Fatty acids, montan-wax and Montan wax
- EC Number:
- 914-468-7
- Molecular formula:
- R-CH2-COOH mainly
- IUPAC Name:
- Reaction mass of Fatty acids, montan-wax and Montan wax
- Details on test material:
- - Name of test material (as cited in study report): Hoechst-Wachs S
- Substance type: yellow flakes
- Physical state: solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: SPF breeding colony
- Strain: Wistar K
- Weight at study initiation: mean 99 g
- Fasting period before study: 16 h
- Diet (e.g. ad libitum): Standard-ALTROMIN R (Altromin GmbH, Lage/Lippe, Germany), ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25% suspension - Doses:
- 15000 mg/kg bw (highest administrable dose), lower doses not stated
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 15 000 mg/kg bw
- Remarks on result:
- other: no animal died within the observation period
Any other information on results incl. tables
- no animal died during the test
- all animals showed normal behaviour after application
- body weight development was not impaired
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information CLP-Regulation
- Conclusions:
- Single application of 15000 mg test substance (Hoechst-Wachs S) per kg bw did not cause lethality in female Wistar-rats within the 14 day observation period, resulting in a LD50 > 15000 mg/kg bw.
- Executive summary:
Ten female Wistar-rats were subjected to test acute oral toxicity. The test substance (Hoechst-Wachs S) was administered by gavage at the highest applicable dose of 15000 mg/kg bw. No animal died under these conditions, resulting in a LD50 > 15000 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
