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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from peer reviewed journals

Data source

Reference
Reference Type:
publication
Title:
Range-finding toxicity data: list VIII
Author:
CARPENTER et. al.
Year:
1974
Bibliographic source:
TOXICOLOGY AND APPLIED PHARMACOLOGY

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the extent of ocular injury caused by the given test chemical in rabbits
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Hexyl acetate
EC Number:
205-572-7
EC Name:
Hexyl acetate
Cas Number:
142-92-7
Molecular formula:
C8H16O2
IUPAC Name:
Hexyl acetate
Test material form:
liquid
Details on test material:
Name of the test chemical: Hexyl acetate
Molecular formula: C8H16O2
Molecular Weight: 144.212 g/mol
Substance Type: Organic
Physical State: Liquid
Specific details on test material used for the study:
Name of the test chemical: Hexyl acetate
Molecular formula: C8H16O2
Molecular Weight: 144.212 g/mol
Substance Type: Organic
Physical State: Liquid

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
no data available

Test system

Vehicle:
unchanged (no vehicle)
Controls:
yes
Amount / concentration applied:
0.5 ml
Duration of treatment / exposure:
no data available
Observation period (in vivo):
no data available
Duration of post- treatment incubation (in vitro):
no data available
Number of animals or in vitro replicates:
no data available
Details on study design:
TEST SITE
Area of exposure: eye
% coverage: No data
Type of wrap if used: no wrap used

REMOVAL OF TEST SUBSTANCE
Washing (if done): no data
Time after start of exposure: no data

SCORING SYSTEM:
Grade 1 indicates at most a very small area of necrosis resulting from 0.5 ml of undiluted chemical in the eye. Grade 5 indicates a so-called severe burn from 0.005 ml, and Grade 10 indicates a severe burn from 0.5 ml of a 1% solution in water or propylene glycol

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: no data available
Score:
1
Max. score:
10
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No irritation observed

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
Primary Eye Irritation score after 24 hours for the given test chemical was Grade 1.
Based on the grade, it was considered to be not irritating to eyes.
Executive summary:

An eye irritation study was carried out by using the given test chemical to evaluate the irritation potential. 0.5 ml of undiluted chemical was instilled into the eye of rabbits. Observations were made after instillation of test chemical. Eye injury in rabbits was recorded in a 10- grade ordinal series and was based upon the degree of corneal necrosis that results from instillation of various volumes and concentrations of chemical. Primary Eye Irritation score after 24 hours for the given test chemical was Grade 1.

Based on the grade, it was considered to be not irritating to eyes.