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EC number: 229-755-6 | CAS number: 6707-60-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 Mar to 8 April 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Principles of method if other than guideline:
- The test evaluated ready and ultimate biodegradability.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 12-oxahexadecan-16-olide
- EC Number:
- 229-755-6
- EC Name:
- 12-oxahexadecan-16-olide
- Cas Number:
- 6707-60-4
- Molecular formula:
- C15H28O3
- IUPAC Name:
- 1,6-dioxacycloheptadecan-7-one
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Test material name (as stated in the report): Cervolide
Sample Code : R675
Purity : 98.00%
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- the inoculum used was 10% by volume of activated sludge plant secondary effluent, filtered through a Whatman filter paper (541) to remove coarse particulate matter. The level of dissolved inorganic carbon (DIC) was reduced by sparging the filtered effluent with nitrogen after prior adjustment of the PH to 6.5
- Duration of test (contact time):
- 28 d
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- The test used was the 160mL sealed vessel containing 100 ml mineral salts medium inoculated with secondary effluent and the respective test or reference substance. The headspace in each vessel has a volume of 60 ml and filled with air. The sealed vessels are incubated at 20 on a rotary shaker. At intervals during the 28 day test period a vessel is removed and concentration of carbon dioxide in the headspace gas determined. The total inorganic carbon in the vessel is calculated and corrected by subtracting the total inorganic carbon produced in a control. The extent of mineralisation can by determined by the initial organic carbon concentration added as test substance
Results and discussion
% Degradation
- Key result
- Parameter:
- % degradation (inorg. C analysis)
- Value:
- 96.5
- Sampling time:
- 28 d
- Remarks on result:
- other: 95% CL (82.8-110.2%)
Any other information on results incl. tables
The percentage biodgradation is given by:
(TICt-TICc)/TC*100%
TICt=total inorganic carbon in test bottle
TICc=total inorganic carbon in control bottle
TC=organic carbon after reference to the appropriate inorganic carbon standard curve
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The test substance was assessed to have achieved 96.5 % (95 % CL of 82.8 to 110.2) degradation after 28 days. Therefore Rhubafuran can be considered to be readily and ulimately biodegradable.
- Executive summary:
The ready and ultimate biodegradability of the test substance was examined in a CO2evolution test with similarities to OECD 301B and to GLP standard.
Biodegradation of Day 4,8,14,22,24 and 28 is determined as 35.8%, 71.4%, 92.6%, 80.7%, 89.0% and 96.5%, respectively. The test substance was assessed to have achieved 96.5 % (95 % CL of 82.8 to 110.2) degradation after 28 days. Therefore Rhubafuran can be considered to be readily and ulimately biodegradable.
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