Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 229-755-6 | CAS number: 6707-60-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1977
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Testing was performed before OECD guideline published.
- GLP compliance:
- no
Test material
- Reference substance name:
- 12-oxahexadecan-16-olide
- EC Number:
- 229-755-6
- EC Name:
- 12-oxahexadecan-16-olide
- Cas Number:
- 6707-60-4
- Molecular formula:
- C15H28O3
- IUPAC Name:
- 1,6-dioxacycloheptadecan-7-one
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- name of testing material: 77-227 Hibiscolide
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
Results and discussion
- Preliminary study:
- Acute oral toxicity in rates
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- 10 rats were used in the study. The animals were observed over a 14 day period for mortality and/or systemic effects. A gross necropsy was conducted on all animals.
The oral LD50 of 12-oxahexadecanolide in rats exceeded 5000 mg/kg with 0/10 deaths at that dose - Executive summary:
The oral LD50 of 12-oxahexadecanolide in rats exceeded 5000 mg/kg with 0/10 deaths at that dose.
Cevolide does not met the criteria for classication according the CLP Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
