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Diss Factsheets
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EC number: 272-037-2 | CAS number: 68649-89-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals
Data source
Reference
- Reference Type:
- publication
- Title:
- Safety Assessment of Monoglyceryl Monoesters as Used in Cosmetics
- Author:
- Monice M. Fiume, Bart A. Heldreth
- Year:
- 2 015
- Bibliographic source:
- Cosmetic Ingredient Review, December 14-15, 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the dermal irritation potential of Glycerol esters of rosin in rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Resin acids and Rosin acids, esters with glycerol
- EC Number:
- 232-482-5
- EC Name:
- Resin acids and Rosin acids, esters with glycerol
- Cas Number:
- 8050-31-5
- IUPAC Name:
- Glycerol esters of rosin
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report):Glyceryl Rosinate
- IUPAC name: Resin acids and Rosin acids esters with glycerol
- Substance type:Organic
- Physical state:Solid
- Purity:No data available
- Impurities (identity and concentrations):No data available
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):Glyceryl Rosinate
- IUPAC name: Resin acids and Rosin acids esters with glycerol, Glycerol esters of rosin
- Substance type:Organic
- Physical state:Solid
- Purity:No data available
- Impurities (identity and concentrations):No data available
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- no data available
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: intact skin
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- semi-occlusive patch applied to intact skin; 0.5 g applied
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- up to 72 hours
- Number of animals:
- 3
- Details on study design:
- no data available
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No erythema or edema was observed
Any other information on results incl. tables
Table: Results of the primary irritation study – dermal
Name of the test chemical |
Concentration/ dose |
Number of animals/ group |
Procedure |
Results |
Glyceryl rosinate |
No vehicle, but moistened with water, 0.5g |
3 New Zealand White rabbits |
4h semi occlusive patch, intact skin, 0.5 g applied to skin, animals were observed up to 72 hours |
No erythema and no edema. Not irritating |
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- No erythema or edema was observed in the rabbits during the 72 hour observation period.
Glycerol esters of rosin was considered to be not irritating to rabbit skin. - Executive summary:
The irritant effects on rabbit skin, was assessed for glyceryl rosinate. 3 New Zealand White Rabbits were subjected to a 4-h semi-occlusive patch test. 0.5 g test chemical was applied to intact skin, no vehicle was used but test chemical was moistened with distilled water. Animals were observed for up to 72 h
No erythema or edema was observed in the rabbits during the 72 hour observation period.
Glycerol esters of rosin was considered to be not irritating to rabbit skin.
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