ethametsulfuron-methyl (ISO); methyl 2-[(4-ethoxy-6-methylamino-1,3,5-triazin-2-yl)carbamoylsulfamoyl]benzoate

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2009

Report date:

2010

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7840 (Water Solubility)

Deviations:

no

GLP compliance:

yes

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

Reference substance 002

Cas Number:

97780-06-8

Test material form:

solid

Details on test material:

- Purity: 100%

Results and discussion

Water solubility

Water solubility 1

Key result

Water solubility:

0.017 g/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

6.69

Remarks on result:

other: 0.0168 ± 0.0012

Remarks:

Milli-Q water

Water solubility 2

Key result

Water solubility:

0.001 g/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

4

Remarks on result:

other: 0.00056 ± 0.00002

Water solubility 3

Key result

Water solubility:

0.223 g/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

7

Remarks on result:

other: 0.2227 ± 0.0008

Water solubility 4

Key result

Water solubility:

1.858 g/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

9

Remarks on result:

other: 1.8584 ± 0.0308

Any other information on results incl. tables

Milli-Q Water

The overall mean solubility of the test item in Milli-Q water was determined to be 0.0168 ± 0.0012 g/L at 20 ± 0.5°C. The successive analysed values showed a percent difference in mean solubility on different days, in the range of 2.2 to 14% and the test item was considered to be at equilibrium as the difference in concentration of the test item in the supernatants between the sampling intervals was less than 15%.

pH 4.0 Buffer

The overall mean solubility of the test item in pH 4.0 buffer was determined to be 0.00056 ± 0.00002 g/L at 20 ± 0.5°C. The successive analysed values showed a percent difference in mean solubility on different days, in the range of 1.8 to 3.4% and the test item was considered to be at equilibrium as the difference in concentration of the test item in the supernatants between the sampling intervals was less than 15%.

 pH 7.0 Buffer

The overall mean solubility of the test item in Milli-Q water was determined to be 0.2227 ± 0.0008 g/L at 20 ± 0.5°C. The successive analysed values showed a percent difference in mean solubility on different days, in the range of 0.0 to 0.4% and the test item was considered to be at equilibrium as the difference in concentration of the test item in the supernatants between the sampling intervals was less than 15%.

pH 9.0 Buffer

The overall mean solubility of the test in pH 9.0 buffer was determined to be 1.8584 ± 0.0308 g/L at 20 ± 0.5°C. The successive analysed values showed a percent difference in mean solubility on different days, in the range of 0.6 to 1.8% and the test item was considered to be at equilibrium as the difference in concentration of the test item in the supernatants between the sampling intervals was less than 15%.

SOLVENT	REPLICATION	SOLUBILITY(G/L)
		SAMPLINGDURATION			OVERALLMEAN
		24 HOUR	48 HOUR	72 HOUR
Milli-Q Water	R1	0.0153	0.0178	0.0174	0.0168 ± 0.0012
	R2	0.0145	0.0175	0.0174
	R3	0.0162	0.018	0.0175
	Mean ± s.d.	0.0153 ± 0.0009	0.0178 ± 0.0003	0.0174 ± 0.0001
pH 4.0 Buffer Solution	R1	0.00054	0.00057	0.00058	0.00056 ± 0.00002
	R2	0.00055	0.00055	0.00058
	R3	0.00055	0.00055	0.00059
	Mean ± s.d.	0.00055 ± 0.00001	0.00056 ± 0.00001	0.00058 ± 0.00001
pH 7.0 Buffer Solution	R1	0.2224	0.2219	0.2226	0.2227 ± 0.0008
	R2	0.2231	0.2243	0.2222
	R3	0.2234	0.2227	0.2219
	Mean ± s.d.	0.2230 ± 0.0005	0.2230 ± 0.0012	0.2222 ± 0.0004
pH 9.0 Buffer Solution	R1	1.8708	1.8503	1.8054	1.8584 ± 0.0308
	R2	1.8778	1.883	1.8094
	R3	1.8826	1.8644	1.8818
	Mean ± s.d.	1.8771 ± 0.0059	1.8659 ± 0.0164	1.8322 ± 0.0430

Applicant's summary and conclusion

Conclusions:

Mean water solubility of the test item in Milli-Q water, buffer solutions of pH 4.0, 7.0, and 9.0 was 0.0168 ± 0.0012, 0.00056 ± 0.00002, 0.2227 ± 0.0008 and 1.8584 ± 0.0308 g/L, respectively at 20 ± 0.5°C.

Executive summary:

This study was conducted to determine the water solubility of the test substance. The water solubility was determined according to Organization for Economic Co-operation and Development Guidelines – OECD 105 and OPPTS 830.7840. The solubility of the test substance was studied in Milli-Q water, buffer solutions of pH 4, 7, and 9 at 20 ± 0.5°C, using the shake flask method. The samples were analysed by high-performance liquid chromatography.

Mean water solubility of the test item in Milli-Q water, buffer solutions of pH 4, 7, and 9 was 0.0168 ± 0.0012, 0.00056 ± 0.00002, 0.2227 ± 0.0008 and 1.8584 ± 0.0308 g/L in Milli-Q water, buffer solutions of pH 4, 7 and 9, respectively at 20 ± 0.5°C.