Registration Dossier
Registration Dossier
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EC number: 203-467-0 | CAS number: 107-14-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Smyth H.F.; Carpenter, C.P.; Weil C.S.; Pozzani, U.C.; Striegel, J.A.
- Year:
- 1 962
- Bibliographic source:
- American Industrial Toxicity Data: List VI 23: 95 - 107
- Reference Type:
- secondary source
- Title:
- American Industrial Hygiene Association
- Year:
- 1 962
- Bibliographic source:
- http://www.safe.nite.go.jp/english/ghs/11-mhlw-0074e.html Original source: American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.
Materials and methods
- GLP compliance:
- no
- Test type:
- traditional method
- Limit test:
- no
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Remarks on duration:
- observation period 14 days
- Concentrations:
- nominal concentrations in an essentially logarithmic series with a factor of 2
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LCLo
- Effect level:
- 0.772 mg/L air
- Based on:
- test mat.
- Remarks on result:
- other: equivalent to 250 ppm
- Mortality:
- 1 death in 6 animals
- Clinical signs:
- other: not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
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