Registration Dossier
Registration Dossier
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EC number: 203-467-0 | CAS number: 107-14-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Smyth H.F.; Carpenter, C.P.; Weil C.S.; Pozzani, U.C.; Striegel, J.A.
- Year:
- 1 962
- Bibliographic source:
- American Industrial Toxicity Data: List VI 23: 95 - 107
- Reference Type:
- secondary source
- Title:
- American Industrial Hygiene Association
- Year:
- 1 962
- Bibliographic source:
- http://www.safe.nite.go.jp/english/ghs/11-mhlw-0074e.html Original source: American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- Chloroacetonitrile
- EC Number:
- 203-467-0
- EC Name:
- Chloroacetonitrile
- Cas Number:
- 107-14-2
- Molecular formula:
- C2H2ClN
- IUPAC Name:
- 2-chloroacetonitrile
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- albino rabbits
Test system
- Type of coverage:
- open
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.01 ml undiluted
- Duration of treatment / exposure:
- 24 h
- Observation period:
- not indicated
- Number of animals:
- 5
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 10
- Reversibility:
- not specified
- Irritant / corrosive response data:
- Only slight congestion in blood capillary, rated as Grade 2 (mild irritant) on a scale of 1 to 10, it was classified as "Not classified" in JIS classification (Category 3 in UN GHS classification).
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 (mild irritant) based on GHS criteria
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