Registration Dossier

Diss Factsheets

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Hydrolysis:

The hydrolysis half life at different pH and rate constant of test chemical 2-phenylethyl pentanoate (CAS No. 7460-74-4) was estimated by EPI  Suite (HydroWin). The Half life estimated at pH 7 was 2.842 years and at pH 8 was 103.820 days at temperature 25 oC. The rate Constant at pH > 8 was 7.727E-002 L/Mol/Sec  at 25 oC. Since, half life of hydrolysis of chemical 2-phenylethyl pentanoate is more than 10 days it shows negligible hydrolysis in water.

Additional information

Hydrolysis:

Results of predicted data study for target chemical 2-phenylethyl pentanoate (CAS No. 7460-74-4) and experimental studies for its read across chemical for hydrolysis endpoint are summarized below.

The hydrolysis half life at different pH and rate constant of test chemical 2-phenylethyl pentanoate (CAS No. 7460-74-4) was estimated by EPI Suite (HydroWin). The Half life estimated at pH 7 was 2.842 years and at pH 8 was 103.820 days at temperature 25 oC. The rate Constant at pH > 8 was 7.727E-002 L/Mol/Sec at 25 oC. Since, half life of hydrolysis of chemical 2-phenylethyl pentanoate is more than 10 days it shows negligible hydrolysis in water.

 

In a supporting weight of evidence study for read across chemical from authoritative database ( HSDB, 2017) the half-life of the read across chemical benzyl acetate (CAS no. 140-11-4) was determined using an estimated pseudo-first order hydrolysis rate constant of 0.00000021/sec at a temperature of 25°C and pH 7.0, respectively. The half-life of benzyl acetate was determined to be 38 days at pH 7. Based on the half-life values, it is concluded that the read across chemical benzyl acetate is not hydrolysable

 

In another supporting weight of evidence study from same source as mentioned above the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method for read across chemical 2-phenylethyl propanoate (CAS no. 122-70-3). The second order hydrolysis rate constant of 2-phenylethyl propanoate was determined to be 0.13 L/mol-sec with corresponding half-lives of 1.7 yrs and 63 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the chemical 2-phenylethyl propanoate is not hydrolysable.

 

On the basis of results of all above mentioned studies it is concluded that test chemical 2-phenylethyl pentanoate (CAS No. 7460-74-4) is not hydrolysable.