Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-246-9 | CAS number: 7460-74-4
Endpoint summary
Administrative data
Description of key information
Hydrolysis:
The hydrolysis half life at different pH and rate constant of test chemical 2-phenylethyl pentanoate (CAS No. 7460-74-4) was estimated by EPI Suite (HydroWin). The Half life estimated at pH 7 was 2.842 years and at pH 8 was 103.820 days at temperature 25 oC. The rate Constant at pH > 8 was 7.727E-002 L/Mol/Sec at 25 oC. Since, half life of hydrolysis of chemical 2-phenylethyl pentanoate is more than 10 days it shows negligible hydrolysis in water.
Additional information
Hydrolysis:
Results of predicted data study for target chemical 2-phenylethyl pentanoate (CAS No. 7460-74-4) and experimental studies for its read across chemical for hydrolysis endpoint are summarized below.
The hydrolysis half life at different pH and rate constant of test chemical 2-phenylethyl pentanoate (CAS No. 7460-74-4) was estimated by EPI Suite (HydroWin). The Half life estimated at pH 7 was 2.842 years and at pH 8 was 103.820 days at temperature 25 oC. The rate Constant at pH > 8 was 7.727E-002 L/Mol/Sec at 25 oC. Since, half life of hydrolysis of chemical 2-phenylethyl pentanoate is more than 10 days it shows negligible hydrolysis in water.
In a supporting weight of evidence study for read across chemical from authoritative database ( HSDB, 2017) the half-life of the read across chemical benzyl acetate (CAS no. 140-11-4) was determined using an estimated pseudo-first order hydrolysis rate constant of 0.00000021/sec at a temperature of 25°C and pH 7.0, respectively. The half-life of benzyl acetate was determined to be 38 days at pH 7. Based on the half-life values, it is concluded that the read across chemical benzyl acetate is not hydrolysable
In another supporting weight of evidence study from same source as mentioned above the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method for read across chemical 2-phenylethyl propanoate (CAS no. 122-70-3). The second order hydrolysis rate constant of 2-phenylethyl propanoate was determined to be 0.13 L/mol-sec with corresponding half-lives of 1.7 yrs and 63 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the chemical 2-phenylethyl propanoate is not hydrolysable.
On the basis of results of all above mentioned studies it is concluded that test chemical 2-phenylethyl pentanoate (CAS No. 7460-74-4) is not hydrolysable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
