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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
no data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards with acceptable restrictions.

Data source

Reference
Reference Type:
publication
Title:
Preliminary studies of the caries inhibiting potential and acute toxicity of sodium monofluorophosphate
Author:
Shourie KL, Hein JW & Hodge HC
Year:
1950
Bibliographic source:
J. D. Res. 29():529

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: no data
Deviations:
not specified
Principles of method if other than guideline:
One hundred and five albino rats were given graded doses from 74 mg/ kg to 465 mg/ kg of sodium monoflurophosphate as a 5% aqueous solution. The route of administration was intraperitoneal injection, the number of animals dead in 24 hours was used to calculate the LD50.
GLP compliance:
not specified
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Disodium fluorophosphate
EC Number:
233-433-0
EC Name:
Disodium fluorophosphate
Cas Number:
10163-15-2
Molecular formula:
FH2O3P.2Na
IUPAC Name:
disodium fluorophosphate
Details on test material:
- Name of test material (as cited in study report): sodium monofluorophosphate

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS

- Weight at study initiation: 200-300 grams

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Details on exposure:
no data
Doses:
Graded doses from 74 mg/ kg to 465 mg/ kg of sodium monoflurophosphate as a 5% aqueous solution.
No. of animals per sex per dose:
105 rats were divided into 13 groups of five to ten animals.
Control animals:
not specified
Details on study design:
The number of animals dead within a 24 h observation period were used to calculate the LD50 of the compound
Statistics:
From the number of animals dead in 24 h the LD50 was calculated by use of the Winthrop logarithmic-probit graph paper.

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
220 mg/kg bw
Remarks on result:
other: ± 32 mg/ kg standard error
Mortality:
On the basis of Fluoride content alone the LD50 is 29 mg/ kg
Clinical signs:
No data.
Body weight:
No data.
Gross pathology:
No data.
Other findings:
No data.

Any other information on results incl. tables

No data.

Applicant's summary and conclusion

Conclusions:
The LD50 of sodium monofluorophosphate was 220 ± 32 mg/ kg bodyweight in rats weighing 200 to 300 grams.