Registration Dossier
Registration Dossier
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EC number: 296-292-4 | CAS number: 92457-12-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- Simmondsia Chinensis (Jojoba) Seed Wax
- Cas Number:
- 61789-91-1
- Molecular formula:
- C42 H84 O2
- IUPAC Name:
- Simmondsia Chinensis (Jojoba) Seed Wax
- Test material form:
- solid: flakes
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- The subcutaneous toxicity of Simmondsia Chinensis (Jojoba) Seed Wax was evaluated using 3 groups of 6-week-old male rats (10 rats/group)
Administration / exposure
- Type of coverage:
- other: subcutaneous
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The 2 experimental groups received subcutaneous injections of the substance (1 ml/kg/bw) 6 days per week for 7 weeks
- Duration of exposure:
- 7 weeks
- Doses:
- 1 mL/kg/BW
- No. of animals per sex per dose:
- 3 groups of 6-week-old male rats (10 rats/group)
- Control animals:
- yes, concurrent vehicle
- Remarks:
- Refined olive oil
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- other: NOAEL
- Effect level:
- >= 1 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- no indication of skin irritation up to the relevant limit dose level
- Mortality:
- none
- Clinical signs:
- other: none
- Other findings:
- a slight increase in liver weight relative to the increase in body weight observed, no significant differences in body weight or organ weight between experimental and control groups, nor microscopic changes in the skin or in any of the other organs.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Simmondsia Chinensis (Jojoba) Seed Wax is considered not harmful by dermal route.
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