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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Water solubility:
11.3 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
5 other: g/100 mL water
Incubation duration:
> 24 - < 72 h
Temp.:
20 °C
pH:
2.9
Details on results:
Validation
The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 500 to 5.0 x 103 mg/L. The results were satisfactory with a goodness of fit coefficient (r2) of 1.000 being obtained.
Discussion
On completion of the equilibration period, the sample solutions were clear and colorless, with much excess, undissolved test item present. The solutions were decanted, centrifuged and then sampled excluding this excess, undissolved test item. Each supernatant was visually
observed to be clear, colorless and free from undissolved test item prior to diluting for analysis. All individual water solubility result were within ± 15% of the mean, thus satisfying the criteria specified in the guidelines.
Conclusions:
The water solubility of Chlorohexanol has been determined to be 11.3 g/L of solution at 20.0 ± 0.5 °C.
Executive summary:

The water solubility of Chlorohexanol has been determined to be 11.3 g/L of solution at 20.0 ± 0.5 °C, using a flask method designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

Description of key information

The water solubility of the 1 -chloro-6-hexanol has been determined to be 11.3 g/L of solution at 20.0 ± 0.5 °C.

Key value for chemical safety assessment

Water solubility:
11.3 g/L
at the temperature of:
20 °C

Additional information