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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Follows EU Method A.4 (vapour pressure)
Reason / purpose:
reference to same study
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
GLP compliance:
yes
Remarks:
certificate in study report
Type of method:
effusion method: by loss of weight or by trapping vaporisate
Temp.:
ca. 85 °C
Vapour pressure:
< 0.001 Pa
Transition / decomposition:
yes
Transition temp.:
> 100 - < 150 °C
Vapour pressure at 10°C above transition temperature:
0.001 Pa
Vapour pressure at 20°C above transition temperature:
0.001 Pa

A first assay was made; the mass of sample weighed was 9.29 mg. The sample was placed in a Knudsen effusion cell with anaperture size of A = 279.9 μm. Then the cell wasplaced in the apparatus. Due to its chemical structure (long hydrocarbon chain), the test item was considered to have a low vapour pressure. Therefore, the first testing temperatures chosen were 100 °C and 110 °C so as to record an eventual loss of mass .

Temperature step at 100 °C and 110 °C were made. A loss of mass was observed with an important background noise. After being heated, only a blackened liquid residue resolidified was observed instead of a white powder before the beginning of the test.

A degradation of the test item was recorded, the loss of mass observed corresponds to degradation products and not to the test item (see ANNEX 3-1). This degradation explained the background noise and was confirmed by the results obtained with the test EC

A1 during DEFITRACES study No. 12-919041-001.

A second assay was made with a lower temperature; the mass of sample weighed was 6.17 mg. The sample was placed in a Knudsen effusion cell with an aperture size of A = 279.9 μm. Then the cell was placed in the apparatus.

The test EC A1 during DEFITRACES study No. 12-919041-001 showed a decomposition of the test item at about 100 °C. As the temperature of the test should be at least lower than 10 °C of a phase transition, a tem perature step at 85 °C was made. The test

item was a white powder before and after the test but no loss of mass was weighed.

With the experiments and results described above we can conclude that the vapour pressure of 2-(HEXADECANOYLAMINO) ACETIC ACID was considered to be lower than 10-3 Pa (pressure limit of the apparatus) at 85 °C.

The vapour pressure of 2-(HEXADECANOYLAMINO) ACETIC ACID was therefore largely lower than 10-3 Pa at 25 °C.

Conclusions:
The vapour pressure of 2-(hexadecanoylamino) acetic acid was considered to be lower than 0.001 Pa (pressure limit of the apparatus) at 85 °C.
The vapour pressure of 2-(hexadecanoylamino) acetic acid was therefore largely lower than 0.001 Pa at 25 °C.

Description of key information

In compliance with Commission Regulation (EC) No. 761/2009 - EC A4 method (2009) and OECD Guideline No. 104 (2006)

The vapour pressure of 2-(HEXADECANOYLAMINO) ACETIC ACID was considered to be lower than 10-3 Pa (pressure limit of the apparatus) at 85 °C.

The vapour pressure of 2-(HEXADECANOYLAMINO) ACETIC ACID was therefore largely lower than 10-3 Pa at 25 °C

Key value for chemical safety assessment

Vapour pressure:
0.001 Pa
at the temperature of:
25 °C

Additional information