Registration Dossier
Registration Dossier
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EC number: 218-880-1 | CAS number: 2273-43-0
Endpoint summary
Administrative data
Description of key information
Bioaccumulation : aquatic/sediments:
Using BCFBAF Program (v3.00) model of EPI suite 2017 the estimated bio concentration factor (BCF) for Butylstannonic acid (CAS No.2273-43-0) is 100 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical Butylstannonic acid is non bioaccumulative in food chain.
Additional information
Bioaccumulation : aquatic/sediments:
Predicted data study for target chemical Butylstannonic acid (CAS No.2273-43-0) and two experimental studies for its structurally similar read across chemical have been conducted and their results are summarized below.
The first weight of evidence was done by using BCFBAF Program (v3.00) model of Estimation Program Interface (EPI suite, 2017 ) and the estimated bio concentration factor (BCF) for Butylstannonic acid (CAS No.2273-43-0) is 100 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000.
Next weight of evidence study was done from authoritative database (2017) in this study the Bioaccumulation test was conducted for 8 weeks for determination the bioconcentration factor (BCF) of test chemical on test organism Cyprinus carpio. The vehicle used in the study was : HCO-20, HCO-60, Olive oil, Crys sugar, and Concentration of vehicle: 1st Concentration area: HCO-20 10000 ppm(w/v), HCO-60 10000 ppm(w/v), Olive oil 2500 ppm(w/v), Crystal sugar 5 ppm(w/v), 2nd Concentration area: HCO-20 1000 ppm(w/v), HCO-60 1000 ppm(w/v), Olive oil 250 ppm(w/v), Crystal sugar 500 ppm(w/v). The recovery ratio was in Test water at 1st concentration area : 100 %, 2nd concentration area : 101 %, Fish : 81.2 %, - Limit of detection : Test water : 1stconcentration area : 0.06 ppm, 2nd concentration area : 0.006 ppm, Fish : 0.3 ppm. Nominal concentrations used was 1st Concentration area: 0.5 mg/L (w/v), 2nd Concentration area: 0.05 mg/L (w/v) and Range finding study was carried out on Rice fish (Oryzias latipes) TLm(48h) 40 ppm(w/v). Thus according to static Fish test The bioconcentration factor (BCF) for test chemical was observed to be <= 0.7 - 18 L/kg at dose concentration 0.5 mg/L and <= 7.1 - 69 L/kg at dose concentration 0.05mg/L on test organism Cyprinus carpio during 8 weeks period. Therefore it is concluded that test chemical is non bioaccumulative.
Last weight of evidence study was done from authoritative database (2017) in this study the BCF value of test chemical estimated was 80 dimensionless by using log Kow of 3.39 and regression derived equation and it is far less than 2000 criteria so it is concluded that test chemical is non bioaccumulative.
On the basis of all the studies mentioned above it can be concluded that target chemical Butylstannonic acid (CAS No.2273-43-0) is non bioaccumulative in nature as all the BCF values are far less than 2000 criteria.
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