Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 265-742-1 | CAS number: 65405-72-3
Toxicological information
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 28.21 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Dermal
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 12.5
- Dose descriptor starting point:
- NOAEL
- Value:
- 400 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 352 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for differences in duration of exposure:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for other interspecies differences:
- 2.5
- Justification:
- Standard ECHA guidance assessment factors.
- AF for intraspecies differences:
- 5
- Justification:
- Standard ECHA guidance assessment factors.
- AF for the quality of the whole database:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for remaining uncertainties:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 28.21 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Dermal
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 12.5
- Dose descriptor starting point:
- NOAEL
- Value:
- 400 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 352 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for other interspecies differences:
- 2.5
- Justification:
- Standard ECHA guidance assessment factors.
- AF for intraspecies differences:
- 5
- Justification:
- Standard ECHA guidance assessment factors.
- AF for the quality of the whole database:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for remaining uncertainties:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 70.53 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 5
- Dose descriptor:
- NOAEC
- Value:
- 352 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for differences in duration of exposure:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for other interspecies differences:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for intraspecies differences:
- 5
- Justification:
- Standard ECHA guidance assessment factors.
- AF for the quality of the whole database:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for remaining uncertainties:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 70.53 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 5
- Dose descriptor starting point:
- NOAEC
- Value:
- 352 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for other interspecies differences:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for intraspecies differences:
- 5
- Justification:
- Standard ECHA guidance assessment factors.
- AF for the quality of the whole database:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for remaining uncertainties:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 8 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Dermal
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 50
- Dose descriptor starting point:
- NOAEL
- Value:
- 400 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for differences in duration of exposure:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Standard ECHA guidance assessment factors.
- AF for other interspecies differences:
- 2.5
- Justification:
- Standard ECHA guidance assessment factors.
- AF for intraspecies differences:
- 5
- Justification:
- Standard ECHA guidance assessment factors.
- AF for the quality of the whole database:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for remaining uncertainties:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 8 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Dermal
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 50
- Dose descriptor starting point:
- NOAEL
- Value:
- 400 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Standard ECHA guidance assessment factors.
- AF for other interspecies differences:
- 2.5
- Justification:
- Standard ECHA guidance assessment factors.
- AF for intraspecies differences:
- 5
- Justification:
- Standard ECHA guidance assessment factors.
- AF for the quality of the whole database:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for remaining uncertainties:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 20 mg/cm²
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 20
- Dose descriptor:
- NOAEC
- Value:
- 352 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for differences in duration of exposure:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Standard ECHA guidance assessment factors.
- AF for other interspecies differences:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for intraspecies differences:
- 5
- Justification:
- Standard ECHA guidance assessment factors.
- AF for the quality of the whole database:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for remaining uncertainties:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 20 mg/cm²
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 20
- Dose descriptor starting point:
- NOAEC
- Value:
- 352 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Standard ECHA guidance assessment factors.
- AF for other interspecies differences:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for intraspecies differences:
- 2.5
- Justification:
- Standard ECHA guidance assessment factors.
- AF for the quality of the whole database:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for remaining uncertainties:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 6.96 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Dermal
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Dose descriptor starting point:
- NOAEL
- Value:
- 400 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 174 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for differences in duration of exposure:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for other interspecies differences:
- 2.5
- Justification:
- Standard ECHA guidance assessment factors.
- AF for intraspecies differences:
- 10
- Justification:
- Standard ECHA guidance assessment factors.
- AF for the quality of the whole database:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for remaining uncertainties:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 6.96 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Dermal
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Dose descriptor starting point:
- NOAEL
- Value:
- 400 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 174 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for other interspecies differences:
- 2.5
- Justification:
- Standard ECHA guidance assessment factors.
- AF for intraspecies differences:
- 10
- Justification:
- Standard ECHA guidance assessment factors.
- AF for the quality of the whole database:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for remaining uncertainties:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 17.39 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 10
- Dose descriptor:
- NOAEC
- Value:
- 174 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for differences in duration of exposure:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for other interspecies differences:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for intraspecies differences:
- 10
- Justification:
- Standard ECHA guidance assessment factors.
- AF for the quality of the whole database:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for remaining uncertainties:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 17.39 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 10
- Dose descriptor starting point:
- NOAEC
- Value:
- 174 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for other interspecies differences:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for intraspecies differences:
- 10
- Justification:
- Standard ECHA guidance assessment factors.
- AF for the quality of the whole database:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for remaining uncertainties:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 4 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Dermal
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Dose descriptor starting point:
- NOAEL
- Value:
- 400 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for differences in duration of exposure:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Standard ECHA guidance assessment factors.
- AF for other interspecies differences:
- 2.5
- Justification:
- Standard ECHA guidance assessment factors.
- AF for intraspecies differences:
- 10
- Justification:
- Standard ECHA guidance assessment factors.
- AF for the quality of the whole database:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for remaining uncertainties:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 4 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Dermal
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Dose descriptor starting point:
- NOAEL
- Value:
- 400 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Standard ECHA guidance assessment factors.
- AF for other interspecies differences:
- 2.5
- Justification:
- Standard ECHA guidance assessment factors.
- AF for intraspecies differences:
- 10
- Justification:
- Standard ECHA guidance assessment factors.
- AF for the quality of the whole database:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for remaining uncertainties:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 10 mg/cm²
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 40
- Dose descriptor:
- NOAEC
- Value:
- 174 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for differences in duration of exposure:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Standard ECHA guidance assessment factors.
- AF for other interspecies differences:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for intraspecies differences:
- 10
- Justification:
- Standard ECHA guidance assessment factors.
- AF for the quality of the whole database:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for remaining uncertainties:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 10 mg/cm²
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 40
- Dose descriptor starting point:
- NOAEC
- Value:
- 174 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Standard ECHA guidance assessment factors.
- AF for other interspecies differences:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for intraspecies differences:
- 10
- Justification:
- Standard ECHA guidance assessment factors.
- AF for the quality of the whole database:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for remaining uncertainties:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 4 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Dermal
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Dose descriptor starting point:
- NOAEL
- Value:
- 400 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for differences in duration of exposure:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Standard ECHA guidance assessment factors.
- AF for other interspecies differences:
- 2.5
- Justification:
- Standard ECHA guidance assessment factors.
- AF for intraspecies differences:
- 10
- Justification:
- Standard ECHA guidance assessment factors.
- AF for the quality of the whole database:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for remaining uncertainties:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 4 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Dermal
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Dose descriptor starting point:
- NOAEL
- Value:
- 400 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Standard ECHA guidance assessment factors.
- AF for other interspecies differences:
- 2.5
- Justification:
- Standard ECHA guidance assessment factors.
- AF for intraspecies differences:
- 10
- Justification:
- Standard ECHA guidance assessment factors.
- AF for the quality of the whole database:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
- AF for remaining uncertainties:
- 1
- Justification:
- Standard ECHA guidance assessment factors.
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
