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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1966
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1956

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
Miller, L.C., and Tainter, M.L.: Proc.Soc. Exper.Biol. Med., 57:261.1944
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline

Test animals

Species:
rat
Strain:
other: albino carworth
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
propylene glycol
Remarks:
also corn oil
Control animals:
yes

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 290 mg/kg bw
Based on:
dissolved
Remarks on result:
other: Dose of coumarin(10% in Propylene Glycol)
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 520 mg/kg bw
Based on:
dissolved
Remarks on result:
other: Dose of coumarin(6% in corn oil)

Any other information on results incl. tables

Acute toxicity in fasted male albino rats following single oral doses of coumarin in propylene

glycol or corn oil

Rat Groups

(10 rats/group 90 grams average body wt)

Dose of Coumarin(10% in Propylene

Glycol)

%Mortality (at 72hr)

Dose of Coumarin(10% in corn oil)

%Mortality

(at 72hr)

 

gm./kgm

0.10

0.20

0.30

0.50

0.70

1.00

1.50

 

0.0

0.0

60.0

100.0

100.0

100.0

100.0

gm./kgm

0.25

0.30

0.50

0.60

0.70

0.80

1.00

 

0.0

10.0

40.0

60.0

90.0

70.0

100.0

LD50±SD1…..

Slope Factor2….

 

0.29±0.03gm/kgm

0.16 gm./kgm

 

0.52±0.03 gm/kgm

0.31 gm./kgm

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information