Registration Dossier
Registration Dossier
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EC number: 609-453-4 | CAS number: 37630-52-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-Propenoic acid, 2-cyano-3-(3,4-dimethoxyphenyl)-, (2E)-
- EC Number:
- 609-453-4
- Cas Number:
- 37630-52-7
- Molecular formula:
- C12H11NO4
- IUPAC Name:
- 2-Propenoic acid, 2-cyano-3-(3,4-dimethoxyphenyl)-, (2E)-
- Test material form:
- solid
- Remarks:
- powder
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- ca. 4
- Reversibility:
- fully reversible
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Remarks:
- The mean value of redness of conjunctivae, cornea opacity and iris irritation scores could not be calculated, due to the severely conjunctivae irritation at 24, 48 and 72 h after the treatment.
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Remarks:
- The mean value of redness of conjunctivae, cornea opacity and iris irritation scores could not be calculated, due to the severely conjunctivae irritation at 24, 48 and 72 h after the treatment.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Remarks:
- The mean value of redness of conjunctivae, cornea opacity and iris irritation scores could not be calculated, due to the severely conjunctivae irritation at 24, 48 and 72 h after the treatment.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- The test item applied to the rabbit eye mucosa, caused conjunctival and corneal irritant effects, fully reversible within three weeks.
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