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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from peer reviewed journals

Data source

Reference
Reference Type:
publication
Title:
Fragrance raw materials monographs: Geranyl formate
Author:
Edited by D. L. J. Opdyke
Year:
1974
Bibliographic source:
Food and Cosmetics Toxicology, Volume 12, Issues 7–8, December 1974, Pages 893-894

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the ocular irritation of Geranyl formate in a rabbit eye irritation tes
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Geranyl formate
EC Number:
203-339-4
EC Name:
Geranyl formate
Cas Number:
105-86-2
Molecular formula:
C11H18O2
IUPAC Name:
3,7-dimethylocta-2,6-dien-1-yl formate
Test material form:
liquid
Details on test material:
Name of test material (as cited in study report):Geranyl formate
Molecular formula: C11H18O2
Molecular weight: 182.261 g/mol
Smiles: C(\CC\C=C(\C)C)(=C\COC=O)C
Substance type: Organic
Physical State: Liquid
Specific details on test material used for the study:
Name of test material (as cited in study report):Geranyl formate
Molecular formula: C11H18O2
Molecular weight: 182.261 g/mol
Smiles: C(\CC\C=C(\C)C)(=C\COC=O)C
Substance type: Organic
Physical State: Liquid

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
no data

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
no data
Duration of treatment / exposure:
72 hours
Observation period (in vivo):
72 hours
Number of animals or in vitro replicates:
no data
Details on study design:
no data

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
72 h
Score:
0
Reversibility:
fully reversible within: 72 hours
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
Slight irritation observed which disappeared after 72 hours

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
Slight irritation was observed in rabbits which disappeared after 72 hours.
Hence Geranyl formate can be considered as not irritating to rabbit eyes.
Executive summary:

A rabbit eye irritation study was conducted to assess the irritation potential of Geranyl formate.

Geranyl formate was instilled into rabbit eyes (number not specified) and the effects were observed for 72 hours.

Slight irritation was observed in rabbits which disappeared after 72 hours.

Hence Geranyl formate can be considered as not irritating to rabbit eyes