N-(2-chloroethyl)-N-ethylaniline

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: hydrolysis determination due to results from pre-test

Deviations:

not applicable

Principles of method if other than guideline:

The test item Toluzonchlorid had to be tested for its water solubility. During the preliminary test it was found that after 24 hours in water the test showed a not negligible decomposition. Hence the water solubility can't be determined.
In a second measurement the hydrolysis was observed over 14 hours. The concentrations of the test item and the hydrolysis compound were screened.

GLP compliance:

yes (incl. QA statement)

Type of method:

other: pre-test; hydrolysis

Test material

Test material information

Constituent 1

Reference substance name:

N-(2-chloroethyl)-N-ethylaniline

EC Number:

245-082-0

EC Name:

N-(2-chloroethyl)-N-ethylaniline

Cas Number:

22564-43-8

Molecular formula:

C11H16ClN

IUPAC Name:

N-(2-chloroethyl)-N-ethylaniline

Results and discussion

Water solubility

Key result

Remarks on result:

not determinable

Details on results:

The water solubility of Toluzonchlorid could not be determined due to the fast hydrolysis. The hydrolysis product was identified as N-Ethyl-N-2-hydroxyethyl-m-toluidine.

Applicant's summary and conclusion

Conclusions:

The water solubility of Toluzonchlorid could not be determined due to the fast hydrolysis. The test item showed a degradation of approx. 50 % in the first 60 minutes. This behaviour occurred also in the next 1 h steps. The hydrolysis product was identified as N-Ethyl-N-2-hydroxyethyl-m-toluidine.

Executive summary:

The test item Toluzonchlorid has been tested for its water solubility in a GLP study (2017).

During the preliminary test it was found that after 24 hours in water the test showed a not negligible decomposition. Hence the water solubility can't be determined.

Therefore the results of the preliminary test are reported:

For the calibration function the test item was solved in acetonitrile. In the HPLC-UV chromatogram there is only one peak assigned to the test item.

After stirring for 24 hours in water the test solution was investigated with HPLC-UV. It was found that the test item showed only small area-percent but there was a second, much bigger peak assigned to a decomposition product.

The pH-value of the test solution was measured. It is determined as between 4 and 5 at the beginning and the end of the stirring time.

The decomposition product was identified with a reference compound.

In a second measurement the hydrolysis was observed over 14 hours. The concentrations of the test item and the hydrolysis compound were screened.

Result: The water solubility of Toluzonchlorid could not be determined due to the fast hydrolysis. The test item showed a degradation of approx. 50 % in the first 60 minutes. This behaviour occurred also in the next 1 h steps. The hydrolysis product was identified as N-Ethyl-N-2-hydroxyethyl-m-toluidine.