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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unnamed
Year:
1995
Report date:
1995
Reference Type:
publication
Title:
Skin Irritation: Reference Chemicals Data Bank
Author:
Bagley et al.
Year:
1996
Bibliographic source:
Toxicology in Vitro 10(1996) 1-6

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium 2-mercaptoethanolate
EC Number:
253-523-3
EC Name:
Sodium 2-mercaptoethanolate
Cas Number:
37482-11-4
Molecular formula:
C2H6OS.Na
IUPAC Name:
sodium 2-sulfanylethan-1-olate
Test material form:
liquid
Specific details on test material used for the study:
- Name of the test item (as cited by study report): 2-mercaptoethanol sodium

Test animals

Species:
rabbit

Test system

Type of coverage:
semiocclusive
Preparation of test site:
not specified
Vehicle:
water
Controls:
no
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied: 1.05 mL
- Concentration: 45.21% (aueous solution)
Duration of treatment / exposure:
3 min
Observation period:
12 days
Number of animals:
3
Details on study design:
TEST SITE
- Area of exposure: the flank

SCORING SYSTEM: Draize scale

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal: #1, #2
Time point:
24/48/72 h
Score:
2
Max. score:
4
Reversibility:
fully reversible within: 7 days
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
<= 4
Max. score:
4
Reversibility:
fully reversible within: 12 days
Remarks on result:
other: Crust formation no erythema scoring possible
Irritation parameter:
edema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
2.67
Max. score:
4
Reversibility:
fully reversible within: 7 days
Remarks on result:
other: Dryness of skin observed during the second and third day
Irritation parameter:
edema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
1.33
Max. score:
4
Reversibility:
fully reversible within: 72 hours
Remarks on result:
other: Dryness of the skin observed at day 7
Irritation parameter:
edema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
4
Max. score:
4
Reversibility:
fully reversible within: 7 days
Irritant / corrosive response data:
One hour after removal of the patch after a 4 hour application to a single animal, signs of lesions through the whole depth of the skin were observed and the animal was sacrificed for humanitarian reasons. After a 3 minute exposure no ulceration or necrosis was seen.

Applicant's summary and conclusion

Interpretation of results:
Category 1B (corrosive) based on GHS criteria