Lithium amide

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Data waiving:

study technically not feasible

Justification for data waiving:

the study does not need to be conducted because the substance is inorganic

Description of key information

In accordance with column 2 Annex VII section 7.8 of Regulation (EC) No 1907/2006 (REACH), the study does not need to be conducted as the substance is inorganic.

Lithium amide is an inorganic compound. Furthermore, lithium amide completely dissociates in water forming lithium hydroxide and the ammonia. Therefore the log Pow of ammonia in water was estimated. The theoretical, calculated (EPIWIN) log Pow of ammonia is 0.23.

Key value for chemical safety assessment

Log Kow (Log Pow):

0.23

at the temperature of:

25 °C

Additional information

Lithium amide quickly dissociate in water forming lithium hydroxide and ammonia. Therefore a laboratory study determining the partition coefficient is technically not feasible and the partition coefficient of the corresponding ammonia was calculated. The calculation of the partition coefficient of ammonia with EPI Suite v4.10 can be seen as rough estimation as only a few inorganic compounds were included in the training data set of the program.
The partition coefficient of ammonia was estimated using KOWWIN v1.68 embedded in EPI Suite v4.10 of EPA’s Office of Pollution Prevention Toxics and Syracuse Research Corporation (SRC). The program is a screening level tool and estimates the log octanol/water partition coefficient log Pow of chemicals using an atom/fragment contribution method. Ammonia has a molecular weight of 17.02 g/mol and therefore does not fit to the applicability domain of this model. Therefore the estimation is regarded as less accurate. A log Pow 0.23 was derived for ammonia.