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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
20 to 24 February 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
yes (incl. QA statement)
Remarks:
Staatliches Gewerbeaufsichtsamt Hildesheim
Type of method:
flask method
Water solubility:
2.479 g/L
Incubation duration:
>= 24 - <= 72 h
Temp.:
20 °C
pH:
ca. 5

 Temperature at Pre-Incubation (30 °C) and Thermostatisation Phase (20 °C) (measured hourly)

Intended temperature

[°C]

Measured temperature

[°C]

Min

Max

Mean value ± SD

30.0 ± 0.5

29.97

30.28

30.06 ± 0.09

20.0 ± 0.5

19.96

20.20

20.00 ± 0.05

Min = Minimum temperature measured

Max = Maximum temperature measured

SD = Standard deviation

 

Check of the pH-value

The pH-values were determined with the remaining test item mixtures in the original test vessels, which were kept constant at 20 ± 0.5 °C.

 

Test temperature [°C]

Pre-incubation

time

[hi

Replicate

Measured

pH

Mean

value

20

24

1

4.709

5.0

2

4.901

48

1

5.040

2

5.032

72

1

5.474

2

4.866

Control

6.824

-

 

Check of the Tyndall-Effect

All samples were checked negative for a Tyndall effect.

 

Water solubility results

No significant signals were obtained for the control sample.

 

Water Solubility Results at 20 °C for test item

 

Preincubation time

Replicate No.

Test item

[g/L]

Concentration [1]

Mean

24 h

1

2.463

2.482

2

2.501

48 h

1

2.487

2.474

2

2.461

72 h

1

2.486

2.482

2

2.479

Mean (24 - 72 h)

 

2.479

Deviation [%] (24 - 72 h) [2]

 

0.3

[1] Mean value of two injections, dilution factor of 100 and exact weight of the standard taken into account.

[2] Calculated according to formula: Deviation [%] = 100 * (max value – min value) / min value.

Conclusions:
A water solubility value of 2.479 g/L (at 20 °C, pH ca. 5.0) was determined for the test substance according to OECD 105.

Description of key information

Water solubility: 2.479 g/L at 20 °C, pH ca. 5.0 (OECD 105, flask method)

Key value for chemical safety assessment

Water solubility:
2.479 g/L
at the temperature of:
20 °C

Additional information