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Partition coefficient

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Endpoint:
partition coefficient
Type of information:
not specified
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
no guideline followed
Principles of method if other than guideline:
The use of secondary sources of data is acceptable when they are based on a critical evaluation of peer-reviewed data and a consequent selection of a reliable and representative values for the properties under investigation.

The study cited was taken from the HSDB and detailed as being peer reviewed and from a authoritative data source and accordingly is considered adequate for assessment as part of a weight of evidence approach.
GLP compliance:
not specified
Type of method:
other: unknown
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
1.71
Remarks on result:
other: No temperature provided.
Conclusions:
The test substance partition coefficient (log Pow) was determined to be 1.71 based on a result taken from peer reviewed handbook data.
Endpoint:
partition coefficient
Type of information:
not specified
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Authoritative database
Qualifier:
no guideline followed
Principles of method if other than guideline:
The authoritative database form the Institute for Occupational Safety and Health of the German Social Accident Insurance (GESTIS database) is regarded as reliable literature source and was taken into account in this weight of evidence approach. The GESTIS database reports the partition coefficient as 1.71.
GLP compliance:
not specified
Type of method:
other: unknown
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
1.71
Remarks on result:
other: No temperature provided
Conclusions:
The test substance partition coefficient (log Pow) was determined to be 1.71 based on a result taken from the GESTIS database.
Endpoint:
partition coefficient
Type of information:
not specified
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
not specified
Principles of method if other than guideline:
The use of secondary sources of data is acceptable when they are based on a critical evaluation of peer-reviewed data and a consequent selection of a reliable and representative values for the properties under investigation.

The study cited was taken from the Japan NITE database which details that an OECD 107 study was conducted on the substance and accordingly is considered adequate for assessment as part of a weight of evidence approach.
GLP compliance:
not specified
Type of method:
flask method
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
1.77
Remarks on result:
other: No temperature provided.
Conclusions:
The test substance partition coefficient (log Pow) was determined to be 1.77 based on a result taken from a secondary source.

Description of key information

A total of two Log Kow values (1.71 and 1.77) are available for this substance based on reliable handbook/secondary source data. The value of 1.77 is selected as the key value for chemical safety assessment as is the most conservative. The method and some experimental details for this test are also available (as well as the test temperature).

Key value for chemical safety assessment

Log Kow (Log Pow):
1.77
at the temperature of:
25 °C

Additional information