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EC number: 201-150-1 | CAS number: 78-85-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions (non-GLP)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Methacrylaldehyde
- EC Number:
- 201-150-1
- EC Name:
- Methacrylaldehyde
- Cas Number:
- 78-85-3
- Molecular formula:
- C4H6O
- IUPAC Name:
- methacrylaldehyde
- Details on test material:
- Methacrolein, CAS No.: 78-85-3
Purity: 96 - 97 %
Stabiliser: 200 ppm hydrochinone
Batch from 1987-06-10
Expiration date September 1987
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomae GmbH, 7950 Biberach
- Age at study initiation: 8-9 weeks
- Weight at study initiation: males 268 ± 7.4 g, females 200 ± 5.4 g
- Fasting period before study: not reported
- Housing: in wire mesh cages type D III (Firma Becker)
- Diet (e.g. ad libitum): KLIBA laboratory diet for rats/mice 24 343-4 10 mm pellet, Klingentalmühle AG, CH-4303 Kaiseraugst, ad libitum
- Water (e.g. ad libitum): drinking water, ad libitum
- Acclimation period: not reported
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24 °C
- Humidity (%): 30-70 %
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light): 12 hrs dark, 12 hrs light
IN-LIFE DATES: From: Day 0 To: Day 14
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- The test substance was used undiluted.
A mixture of vapour with air was generated by using an infusion pump INFU 362 CINDIGEL/ Switzerland and a thermostated glass vaporizer (BASF).
The test substance/air vapour was generated separately for each dose group. The vapours were then mixed with fresh air and were pipelined to the inhalation system. The air flow was uniformly 3000 L/h for each group.
The inhalation chambers were situated in air conditioned rooms, the temperature was 19-25 °C.
The suction air flow was ca. 3 % higher than the supply air flow. - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- Analysis: Gas chromatography (GC HP 5840 A, Hewlett Packard) Glass Column, length: 2 m, inner diameter 2 mm, separation phase: 15 % Ucon LB 550 x, substrate Chromosorb WIHP, 80/100 mesh, carrier gas helium, carrier gas flow: 34 mL/min, hydrogen: 30 mL/min
- Duration of exposure:
- 4 h
- Concentrations:
- 0.19, 0.44 and 0.71 mg/L
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Whole-body exposure system in separated wire-mesh cages (1 animal per cage unit) in a glass-steel inhalation chamber (volume: 200 L)
Sampling for chemical analysis: ca. 1 sample per hour and per concentration, samples taken near the snouts of the animals
Body weight determination before administration, 7 days p.a. and 14 days p.a.
Animal observation at least once daily on working days
Necropsy of all animals with gross pathological examination - Statistics:
- Statistical evaluation of a concentration-effect-relationship according to probit analysis (Finney. D.J.: Probitanalysis 1971, p. 1-150. Published by the Syndics of the Cambridge University Press, Bentley House, 200 Euston Road, London N.W. 1)
Results and discussion
- Preliminary study:
- not applicable
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 0.56 mg/L air (analytical)
- 95% CL:
- 0.47 - 0.66
- Exp. duration:
- 4 h
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- ca. 0.6 mg/L air (analytical)
- Exp. duration:
- 4 h
- Remarks on result:
- other: (following interpolation)
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- ca. 0.5 mg/L air (analytical)
- Exp. duration:
- 4 h
- Remarks on result:
- other: (following interpolation)
- Mortality:
- 0.19 mg/L: 0/10
0.44 mg/L: 1/10
0.71 mg/L: 9/10
see also below (remarks on results) - Clinical signs:
- other: - during exposure: eyelid closure, accelerated and irregular to intermittent respiration, aqueous discharge of eyes and nose, salivation, anaemic aspect, squatting posture. Additional findings in the mid and high dose animals: gasping, apathy, reddis
- Body weight:
- 0.19 mg/L: Mean data (males and females) indicate body weight gain in both weeks p. a. Body weight development for both sexes markedly delayed until day 7 compared to historical control data.
0.44 mg/L: Body weight gain was noted in males in both weeks p. a (mean data). There was a body weight reduction in female's mean data only in the first week p. a. Body weight development for both sexes markedly delayed until day 7 compared to historical control data.
0.71 mg/L: Body weight loss was observed in the surviving male in the first and second week p. a. There was also a body weight reduction in the last female animal after 7 days p. a. - Gross pathology:
- Deceased animals:
0.44 mg/L (1 female): lung: acute emphysema, hardened lobus cranialis
0.71 mg/L (males and females): general congestion hyperaemia, lung: some animals with spotted pneumonia with edge emphysema or atelectical origins
Terminal necropsy:
0.19 and 0.44 mg/L (males and females): no substance related changes
0.71 mg/L: (1 male): lung: emphysematic, lobus cardiacus with pneumonic areas
Any other information on results incl. tables
Cumulative Mortality
treatment |
0.19 mg/L |
0.44 mg/L |
0.71 mg/L |
|||
day |
male |
female |
male |
female |
male |
female |
0 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
1 |
0/5 |
0/5 |
0/5 |
0/5 |
3/5 |
2/5 |
2 |
0/5 |
0/5 |
0/5 |
1/5 |
4/5 |
2/5 |
7 |
0/5 |
0/5 |
0/5 |
1/5 |
4/5 |
4/5 |
14 |
0/5 |
0/5 |
0/5 |
1/5 |
4/5 |
5/5 |
sum |
0/10 |
1/10 |
9/10 |
Applicant's summary and conclusion
- Executive summary:
In an acute inhalation toxicity study (OECD Guideline 403), groups of young adult Wistar rats (5/sex) were exposed by inhalation to Methacrolein for 4 hours to a whole body route at concentrations of 0.19, 0.44, or 0.71 mg/L. Animals then were observed for 14 days.
A total number of 9 animals (4/5 males, 5/5 females) of group 3 (0.71 mg/L) deceased until the end of the study. First deaths (3/5 males, 2/5 females) of this group were recorded on Day 1.
A single female of group 2 (0.44 mg/L) died on Day 2.
There were no deaths in group 1 (0.19 mg/L).
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