Registration Dossier

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2004-11-15 to 2004-11-19
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Specific details on test material used for the study:
Batch:S000034
Purity: 99.5% (GC)
Analytical monitoring:
no
Vehicle:
yes
Details on test solutions:
PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): HCO-40
- Concentration of vehicle in test medium (stock solution and final test solution(s) at different concentrations and in control(s)):
Test item: 100 mg/L , Vehicle: 4 g/L

Test organisms (species):
Oryzias latipes
Details on test organisms:
Weight: 0.3 g
Length: 3.3 cm
Lot: 0408311
Date: 2005-07-29
Test type:
static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
96 h
Post exposure observation period:
no
Test temperature:
24.5 +/- 0.8 °C
Nominal and measured concentrations:
100 mg/L
Details on test conditions:
10 fish per 4 L
Reference substance (positive control):
not specified
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
> 100 mg/L
Nominal / measured:
meas. (initial)
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Remarks on result:
other: with HCO-40 as solibiliser
Sublethal observations / clinical signs:

- Mortality of control: 0 % after 96 hours

Mortality in %

Sample              Mortality / [%]
Test Material  Concentration / [mg/L]  24 h  48 h  72 h 96 h
Test material (+vehicle) 100

 0 

 0

 0

 0

The concentration tested was above the solubility limit of the pure test substance. To achive the exposure concentrations, solubiliser was used.

Validity criteria fulfilled:
yes
Conclusions:
The LC50 of the test material exceeds 100 mg/L and is clearly above the limit of water solubility.
Executive summary:

The information for this endpoint study record was obtained from an experimental study. The OECD GLP criteria were met and the methods applied are fully compliant with OECD TG 203. The LC50 of the test material exceeds 100 mg/L and is clearly above the limit of water solubility.

Description of key information

GLP OECD 203 Assay: NOEC=100 mg/L (measured initial) with solubilizer

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
100 mg/L

Additional information

The LC50 of the test material exceeds 100 mg/L and is clearly above the limit of water solubility.