Octadecanoic acid, reaction products with 2-amino-2-methyl-1-propanol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

The physical state and appearance were determined by visual observation (Scymaris, 2017).

Physical state at 20°C and 1013 hPa:

solid

(off-white cream)

Cross-reference 2

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

The vapour pressure of the test substance was determined experimentally using the static method, according to EU Method A.4, (Chilworth, 2017) as well as using the QSAR models, EPI Suite and TEST (US EPA, 2018).

Vapour pressure:

3.7 Pa

at the temperature of:

20 °C

- Experimental VP = 3.7 Pa at 20 °C (static method); study results are suspected to be influenced by trapped gas/impurities.

- Weighted average QSAR based VP = 0.00179 Pa at 25°C (EPI Suite v.4.11) and 0.000208 Pa at 25°C (T.E.S.T. v4.2.1). The estimates for the major constituents are considered to be reliable with restrictions, as they do not completely fall within of the applicability domain.

- Experimental VP of structurally similar substance, Oleamide MIPA: 2.42E-6 Pa at 25°C (using gas saturation method).

Overall, based on the above information, the test substance can be considered to have low volatility. However, the higher VP value of 3.7 Pa has been considered further for hazard/risk assessment as a conservative approach.