Registration Dossier
Registration Dossier
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EC number: 234-293-3 | CAS number: 11071-15-1
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- other: Bibliographic source
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Metal Toxicity in Mammals, 1.
- Author:
- Luckey, T.D. and B. Venugopal.
- Year:
- 1 977
- Bibliographic source:
- New York: Plenum Press
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Antimony
- EC Number:
- 231-146-5
- EC Name:
- Antimony
- Cas Number:
- 7440-36-0
- Molecular formula:
- Sb
Constituent 1
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- Symptoms of chronic antiimony intoxication are dyspnea, weight and hair loss, papular eruptions on the skin, jaundice, albuminuria, damage to the heart and liver, hyperplasia of the spleen, glomerular nephritis, abnormal increase in erythrocytes, and decrease in leukocytes.
Applicant's summary and conclusion
- Conclusions:
- Chronic inhalation of subtoxic doses of antimony salts causes interstitial pneumonitis, intraalveolar lipoid deposits, and liver and cardiac damage.
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