Registration Dossier
Registration Dossier
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EC number: 202-503-2 | CAS number: 96-37-7
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Remarks:
- pulmonary absoption
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- specific investigations: other studies
- Remarks:
- pulmonary absoption
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- GLP compliance:
- not specified
- Endpoint addressed:
- other: pulmonary absorption
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
- Route of administration:
- inhalation
- Duration of treatment / exposure:
- 80-100 min.
- Details on study design:
- 1000–5000 ppm
Studies on pulmonary absorption of 20 inhaled gasoline-related hydrocarbon vapors — % of inhaled hydrocarbon retained; 80–100 min - Details on results:
- 24.7% Uptake for 2-methyl-pentane
- Conclusions:
- 24.7% uptake of 2-methyl-pentane by pulmonary absoption
- Executive summary:
This is a brief summary of: American Petroleum Institute. 1987. API Med. Res. Pub. 34-33036, October.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- 2-METHYLPENTANE (ISOHEXANE)
- Author:
- Galvin, Jennifer B.; Bond, Gary
- Year:
- 1 999
- Bibliographic source:
- Journal of Toxicology and Environmental Health, Part A, 58:1-2, pp. 81-92, DOI: 10.1080/009841099157449; http://dx.doi.org/10.1080/009841099157449
Materials and methods
- GLP compliance:
- not specified
- Endpoint addressed:
- other: pulmonary absorption
Test material
- Reference substance name:
- 2-methylpentane
- EC Number:
- 203-523-4
- EC Name:
- 2-methylpentane
- Cas Number:
- 107-83-5
- Molecular formula:
- C6H14
- IUPAC Name:
- 2-methylpentane
- Test material form:
- liquid
1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation
- Duration of treatment / exposure:
- 80-100 min.
- Details on study design:
- 1000–5000 ppm
Studies on pulmonary absorption of 20 inhaled gasoline-related hydrocarbon vapors — % of inhaled hydrocarbon retained; 80–100 min
Results and discussion
- Details on results:
- 24.7% Uptake for 2-methyl-pentane
Applicant's summary and conclusion
- Conclusions:
- 24.7% uptake of 2-methyl-pentane by pulmonary absoption
- Executive summary:
This is a brief summary of: American Petroleum Institute. 1987. API Med. Res. Pub. 34-33036, October.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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