Registration Dossier

Administrative data

Description of key information

The key skin irritation study is a guideline rabbit study (Hüls, 1997) which concluded the substance was not irritating to the skin.

The key eye irritation study is a guideline rabbit study (Hüls, 1997) which concluded the substance was not irritating to the eye.

Both studies were conducted according to an OECD guideline and in compliance with GLP.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

2-(Perfluorohexyl)ethyl]triethoxysilane has been tested for acute skin irritation in a semi-occlusive study conducted according to OECD TG 404 and in compliance with GLP (Hüls 1997c). Very slight erythema was observed after 30-60 minutes, and 2, 48 and 72 hours, in two of the three small white Russian rabbits exposed to the undiluted test substance for four hours. One animal showed very slight edema 48 and 72 hours after the removal of the bandage. All signs of irritation had reversed by 6 days after application. One animal showed no signs of skin irritation during the entire observation period. It is concluded that the test substance is not classifiable for irritation to the skin.

In an eye irritation study conducted according to OECD 405 and to GLP, [2-(perfluorohexyl)ethyl]triethoxysilane was only very slightly and transiently irritating to the eyes of small white Russian rabbits and therefore was not classified as an eye irritant.


Justification for classification or non-classification

Based on the available studies on skin and eye irritation, [2-(perfluorohexyl)ethyl]triethoxysilane does not require classification for skin or eye irritation according to Regulation (EC) 1272/2008.