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EC number: 201-796-4 | CAS number: 88-09-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
An LD50 (lethal dose, 50 %) of >2000 mg/kg and 2200 mg/kg was obtained for 2-ethylbutyric acid in two studies for acute toxicity in rats via the oral route. As the former result is more conservative and is based on a reliable study report (Klimisch score = 2), the endpoint conclusion for acute toxicity (oral) is concluded to be >2000 mg/kg. This value is outside of the CLP Regulation (EC) No 1272/2008 criteria and, therefore, the registered substance does not require classification as an acute oral toxin.
An LD50 of 0.52 ml/kg (478 mg/kg) was determined in a range-finding acute toxicity (dermal) experiment involving rabbits. The endpoint conclusion for acute dermal toxicity has been selected as LD50 = 478 mg/kg, which is indicative of the registered substance requiring a classification for Acute Toxicity (Dermal) (Category 3) (CLP Regulation (EC) No 1272/2008). 2-Ethylbutyric acid can be regarded as an acute toxin (Category 3) via the dermal route.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1954
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Insufficient information for an assessment of reliability.
- Principles of method if other than guideline:
- Not available
- GLP compliance:
- not specified
- Test type:
- other: Not available
- Species:
- rat
- Route of administration:
- oral: unspecified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 200 mg/kg bw
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- 2-Ethylbutyric acid was found to have an acute oral LD50 (lethal dose, 50 %) of 2200 mg/kg in rats.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- other: Not available
- Limit test:
- yes
- Species:
- rat
- Strain:
- other: T23-48:Crj:CD(SD)IGS
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 0 (control) and 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 10 - 15 days.
- Frequency of observations and weighing: Hours after administration: 0-1, 2, 3, 4, 5, and 6; Days of observation: 2, 3, 4, 5, 6, 7, 8, 9, and 10-15.
- Necropsy of survivors performed: Yes.
- Other examinations performed: Body weight change measured on days 1, 2, 4, 8, 11, and 15. - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortality
- Clinical signs:
- Transient salivation was evident within 1 hour after the treatment in one male and two females. One male and three females exhibited rales, which continued for several days, and there was a reported decrease in faeces volume and a perianal smudge noted in three males on day 2.
- Body weight:
- Reduction in body weight in both sexes
- Gross pathology:
- No abnormalities
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- An acute oral LD50 (lethal dose, 50 %) of >2000 mg/kg was determined for 2-ethylbutyric acid in male and female rats.
- Executive summary:
A 14-day experiment was undertaken to determine the acute oral toxicity of 2-ethylbutyric acid according to Good Laboratory Practise (GLP) and OECD Guideline 401 (Acute Oral Toxicity). Male and female rats (strain: T23-48:Crj:CD(SD)IGS) were exposed to 0 (control) and 2000 mg/kg in a corn oil vehicle as part of a limit test. Transient salivation was observed in one male and two females at 1-hour and one male and three females exhibited rales, which continued for a number of days. On day 2, three males were observed to have a perianal smudge and decreased faecal volume. Additionally, body weight in exposed rats was significantly lower than the 0 mg/kg control at some observation points. No mortality had been recorded at the termination of the experiment on day 14, nor abnormalities following necropsy that could be associated with the treatment. The acute oral LD50 for 2-ethylbutyric acid was subsequently determined to be 2000 mg/kg, which is outside of the criteria for classification as an acute toxin (oral) (CLP Regulation (EC) No 1272/2008).
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1954
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Insufficient information for an assessment of reliability.
- Principles of method if other than guideline:
- Not available
- GLP compliance:
- not specified
- Species:
- rabbit
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 0.52 mL/kg bw
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- A range-finding acute toxicity (dermal) experiment in rabbits obtained an LD50 (lethal dose, 50 %) of 0.52 ml/kg (478 mg/kg). This value falls within the GHS criteria for classification as Acute Toxicity Category 3 via the dermal route.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 478 mg/kg bw
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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