Registration Dossier
Registration Dossier
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EC number: 214-014-1 | CAS number: 1072-71-5
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017-01-11 - 2018-02-28
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- 13-Apr-04
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material:
sponsor
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material:
At ambient temperature
- Stability under test conditions:
The test item is hydrolytically stable according to OECD 111 tier 1. - Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- < 0
- Temp.:
- 50 °C
- Remarks on result:
- not determinable
- Conclusions:
- The GLP study was performed according to OECD TG 117 without any deviations on the substance to be registered itself, the results were so obtained via a scientifically reasonable method. Hence, there is no doubt that the obtained results are not reliable: A determination of a partition coefficient (n-octanol/water) with the OECD 117 was not possible. Due to the fact that the test item has a retention before the dead time marker the OECD 117 is not valid to determine the log Pow of the test item.
The OECD 117 shows that the log Pow of the test item is < 0.0. - Executive summary:
The test item 2,5-Dimercapto-1,3,4-thiadiazole (“DMTD”) was tested according to OECD-Guideline 117 with the “HPLC-Method” under GLP. According to the definition of the OECD-Guideline 117 the test item shows a log Pow < 0.0. A more precise determination of the log Pow of the test item was not possible.
Reference
Description of key information
Partition coefficient: logPow <0.0 (HPLC method, OECD 117, GLP)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 0
- at the temperature of:
- 50 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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