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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1957
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
no guideline followed
Principles of method if other than guideline:
Test substances were prepared in mixtures of dioxane and water and the rate of degradation of the test substances were followed colormetrically. The dioxane was added to increase the solubility of the test substances.
GLP compliance:
no
Radiolabelling:
no
Analytical monitoring:
yes
Details on sampling:
Test substance, dioxane, water and reagents added together at time 0. Progress of hydrolysis reaction was followed by visual observation of phenolphthalein indicator.
Details on test conditions:

The following procedure was developed for the measurement of the hydrolysis rates. A weighed sample of ester (0.4 to 1.2 mmoles) was dissolved in 15 ml. of purified dioxane . A solution of 10mL of dioxane, 3 drops of phenolphthalein, 15 mL of a 9.09 weight % solution of mannitol in water, and one half of the amount of 0.2457 or 0.1130N sodium hydroxide (approximately 2 mL) necessary for neutralization of the boric acid resulting from complete hydrolysis were added at zero time. The resulting solution was swirled to effect homogeneity and the time for fade of the indicator was recorded as the half life . A blank determination with 1 mmole of boric acid and 0.5 meq. of sodium hydroxide under the above conditions was too fast to measure. Compensation for the phenols liberated in runs with additional base still led to half- lives which were too fast to measure.
Preliminary study:
The test substance hydrolyzes very rapidly in water with a half-ltime 7.8 sec and Relative rate 2.45 X 1000.000 at 21°C
Transformation products:
yes
No.:
#1
No.:
#2
Details on hydrolysis and appearance of transformation product(s):
Hydrolysis products are boric acid and ethanol
Key result
Temp.:
21 °C
DT50:
7.8 s
Type:
not specified
Validity criteria fulfilled:
not applicable
Conclusions:
The test substance hydrolyzes very rapidly in water with a half-ltime 7.8 sec and Relative rate 2.45 x 1000.000 at 21°C
Executive summary:

The test substance hydrolyzes very rapidly in water with a half-ltime 7.8 sec and Relative Rate 2.45 x 1000.000 at 21°C

Description of key information

Triethyl borate has been shown to hydrolyse very rapidly in water with a half-ltime 7.8 sec and Relative Rate 2.45 x 1000.000 at 21°C

Key value for chemical safety assessment

Half-life for hydrolysis:
7.8 s
at the temperature of:
21 °C

Additional information