Registration Dossier
Registration Dossier
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EC number: 218-691-4 | CAS number: 2216-52-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database
Data source
Referenceopen allclose all
- Reference Type:
- other: authoritative database
- Title:
- Acute dermal toxicity study of test chemical was performed in rodents.
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- ChemIDplus, A TOXNET DATABASE, Lite Browse Advanced, 2017
- Reference Type:
- publication
- Title:
- Acute dermal toxicity study of test chemical was performed in rodents.
- Author:
- D. L. J. Opdyke
- Year:
- 1 976
- Bibliographic source:
- Food and Cosmetics Toxicology
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute dermal toxicity of test chemical in rabbits
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- trans-menthone
- EC Number:
- 201-941-1
- EC Name:
- trans-menthone
- Cas Number:
- 89-80-5
- Molecular formula:
- C10H18O
- IUPAC Name:
- (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one
- Details on test material:
- - IUPAC Name: Menthol- InChI: 1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3/t8-,9+,10-/m1/s1- Smiles: CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O- Molecular formula :C10H20O- Molecular weight:156.267 g/mole- Substance type:Organic
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Type of coverage:
- other: Dermal
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- not specified
- Duration of exposure:
- not specified
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed
- Mortality:
- No mortality was observed in treated rabbits at 5000 mg/kg bw
- Clinical signs:
- not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- LD50 was considered to be >5000 mg/kg bw, when rabbits were treated with test chemical by dermal application.
- Executive summary:
The acute dermal toxicity study was conducted by using test chemical in rabbits at the dose concentration of 5000 mg/kg bw. No mortality was observed in treated rabbits at 5000 mg/kg bw.Therefore, LD50 was considered to be >5000 mg/kg bw, when rabbits were treated with test chemical by dermal application.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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