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EC number: 217-683-8 | CAS number: 1929-86-8
Toxicological information
Skin irritation / corrosion
Currently viewing:
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10.10.2006 - 24.10.2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Mecoprop
- EC Number:
- 230-386-8
- EC Name:
- Mecoprop
- Cas Number:
- 7085-19-0
- Molecular formula:
- C10H11ClO3
- IUPAC Name:
- 2-(4-chloro-2-methylphenoxy)propanoic acid
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- water
- Test material form:
- solid
Constituent 1
impurity 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Three white rabbits of New Zealand strain were used in studies.
The rabbits were quarantined for at least 5 days and observed carefully during this time. The used rabbits were: one male 10 months old and two females 9.5 months old weighing on average 3.3 kg.
The day before the start of the experiment animals were shaved with electric razor on back and sides on appropriately big surface. Only those animals that showed no damages and no congestion of skin were used for the experiments.
Test system
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- The powdered test material was given in amount of 0.5 g to multilayered gauze patch with dimensions of 2.5 x 2.5 cm, moistured and then laid on the prepared skin of one rabbit (rabbit No 1). The surface of skin treated with the test material was about 6 cm2. The gauze patches were covered with PCV foil and fixed with sticking plaster. The rabbit back was covered with lignin and elastic bandage was used to make circular protecting band. After 4 hours exposure time the band and gauze patches were taken off and the test material was removed with help of water.
Following evaluation of the exposed skin and to confirm the obtained results the test material was administered to skin of the next two rabbits (rabbit No 2 and No 3) for four hours. The procedure was the same as in case of rabbit No 1. - Duration of treatment / exposure:
- 4 hours
- Observation period:
- Observations of skin were performed after 1, 24, 48 and 72 hours as well as 7 and 14 days since the end of exposure.
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 7 d
- Score:
- 1
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 14 d
- Score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 1
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 7 d
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 14 d
- Score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Max. score:
- 2
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 7 d
- Score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 14 d
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 1
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 7 d
- Score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 14 d
- Score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 2
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 7 d
- Score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 14 d
- Score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 7 d
- Score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 14 d
- Score:
- 0
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- During observation after one hour since the end of exposure on skin in place of exposure all rabbits showed well defined erythema and additionally in rabbits Nos. 1 and 2 very weak (barely visible) edema was noticed. During observation after 24 hours since the end of exposure on skin in place of exposure rabbits Nos. 1 and 2 showed changes similar to those observed after 1 hour since the end of exposure. Rabbit no 3 showed very weak (barely visible) erythema.
During observation after 48 hours since the end of exposure, on skin in place of the exposure well defined erythema was observed in rabbits Nos. 1 and 2. No edema was noticed. Rabbit No 3 still showed very weak (barely visible) erythema.
During observation after 72 hours since the end of exposure rabbits Nos. 1 and 3 showed similar changes on skin in place of exposure as during observation after 48 hours. In rabbit No 2 erythema diminished to very weak (barely visible).
During observation after 7 days since the end of exposure rabbit No 1 showed very weak (barely visible) erythema and dried epidermis. Rabbits Nos. 2 and 3 did not show pathological changes.
During observation after 14 days since the end of exposure rabbit No 1 did not show any pathological changes.
Applicant's summary and conclusion
- Conclusions:
- Taking into account the obtained results, it can be stated that MCPP TECHNICAL does not irritate skin of rabbits.
Substance classified according to Harmonized Classification and Labeling provided in Annex VI of CLP Regulation.
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