Registration Dossier

Diss Factsheets

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
0.003 mg/L
Assessment factor:
100
Extrapolation method:
assessment factor
PNEC freshwater (intermittent releases):
0.025 mg/L

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)
PNEC value:
0 mg/L
Assessment factor:
1 000
Extrapolation method:
assessment factor

STP

Hazard assessment conclusion:
PNEC STP
PNEC value:
0.1 mg/L
Assessment factor:
100
Extrapolation method:
assessment factor

Sediment (freshwater)

Hazard assessment conclusion:
PNEC sediment (freshwater)
PNEC value:
0.046 mg/kg sediment dw
Extrapolation method:
sensitivity distribution

Sediment (marine water)

Hazard assessment conclusion:
PNEC sediment (marine water)
PNEC value:
0.005 mg/kg sediment dw
Extrapolation method:
sensitivity distribution

Hazard for air

Air

Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
PNEC soil
PNEC value:
1 mg/kg soil dw
Assessment factor:
1 000
Extrapolation method:
assessment factor

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
PNEC oral
PNEC value:
0.2 mg/kg food
Assessment factor:
300

Additional information

Fish:

 

Main study:

50% lethal concentration

24-hour 50% lethal concentration (LC50): 2.9 mg/L (95% confidence limit: 2.3-3.8 mg/L),

48-hour 50% lethal concentration (LC50): 2.7 mg/L (95% confidence limit: 2.3-4.7 mg/L),

72-hour 50% lethal concentration (LC50): 2.7 mg/L (95% confidence limit: 2.0-4.0 mg/L),

96-hour 50% lethal concentration (LC50): 2.5 mg/L (95% confidence limit: 1.9-3.7 mg/L)

 

Non-GLP Supporting study:

 

96h LC50 >1.0 mg/l, <10 mg/l.

 

Daphnia:

 

Acute

 

Result after 24 hours

50% effective inhibitory concentration (EC50): > 10 mg/L. The highest concentration causing 0% immobility: 2.1 mg/L. The lowest concentration producing 100 % immobility: > 10 mg/L

 

Result after 48 hours

50% effective inhibitory concentration (EC50): 2.9 mg/L (95% confidence limit: 2.5-3.4 mg/L). The highest concentration causing 0% immobility: 1.5 mg/L. The lowest concentration producing 100 % immobility: 10 mg/L

 

Chronic:

 

The results for this study are taken from the SIDS Initial Assessment Report, For SIAM 4, Tokyo, Japan, 20-22 May 1996, as the full report was not able to be located. The results are considered reliable as a data source used to support the SIDs programme; results collaborate with acute results that could be located. The full report is available at http://www.inchem.org/documents/sids/sids/1879090.pdf. As the lowest chronic toxicity result, the 21 d-NOEC (reproduction) of Daphnia magna (0.32 mg/l) was adopted for the purposes of risk assessment.

Algae:

50% growth inhibition concentration ErC50 (0-48): 5.4 mg/L (95% confidence limit: 5.0-5.9 mg/L)

 

Maximum no effect concentration NOEC (Rate 0-48): 0.40 mg/L

 

50% growth inhibition concentration ErC50 (0-72): 6.0 mg/L (95% confidence limit: 5.3-6.6 mg/L)

 

Maximum no effect concentration NOEC (Rate 0-72): 0.38 mg/L

 

Micro-organisms:

 

EC50 (3 hour contact time) >10 mg/l.

 

Conclusion on classification

On the basis of the results noted in the studies, classification under the Dangerous Substance Directive (67/548/EEC) and the CLP Regulation (EC No 1272/2008 is as follows:

 

N; R51/53 Dangerous for the environment; Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.

Chronic aquatic toxicity, Category 2; H411: Toxic to aquatic life with long lasting effects.