Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

An acute oral toxicity study was conducted on one NDI category member, Reaction product of 1,5-naphthylene diisocyanate and cyclohexylamine. The result of this study showed no evidence of acute toxicity up to the highest dose tested (2000 mg/kg test item in hexane). There is no evidence of a relevant intrinsic acute oral toxicity requiring classification or substance specific risk management measures.

Key value for chemical safety assessment

Additional information

PU NDI substances all contain the same core structure, with either cyclic groups or linear alkyl chains attached. PU NDI structures are therefore similar between all category members, and organisms will be exposed to very similar compounds. Organisms would be exposed to common structures, only differing by the functional groups attached to the core structure. In the body, there may be metabolism of the PU NDI structures, however due to the structural similarity of the parent compounds any metabolites are also likely to be similar. 

Justification for classification or non-classification

The oral LD50 value is greater than 2000 mg/kg bw in the study conducted on the NDI category substance, therefore, existing data supports justification for non-classification. This conclusion is also considered to be appropriate for other substances in the NDI category.