Registration Dossier
Registration Dossier
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EC number: 923-466-5 | CAS number: -
Endpoint summary
Administrative data
Description of key information
An acute oral toxicity study was conducted on one NDI category member, the Reaction product of 1,5-naphthylene diisocyanate and cyclohexylamine. The result of this studies showed no evidence of acute toxicity up to the highest dose tested (2000 mg/kg test item in hexane). There is no evidence of a relevent intrinsic acute oral toxicity requiring classification or substance specific risk management measures.
Key value for chemical safety assessment
Additional information
PU NDI substances all contain the same core structure, with either cyclic groups or linear alkyl chains attached. PU NDI structures are therefore similar between all category members, and organisms will be exposed to very similar compounds. Organisms would be exposed to common structures, only differing by the functional groups attached to the core structure. In the body, there may be metabolism of the PU NDI structures, however due to the structural similarity of the parent compounds any metabolites are also likely to be similar.
Justification for classification or non-classification
The oral LD50 value is greater than 2000 mg/kg bw in the study conducted on the NDI category substance, therefore, existing data supports justification for non-classification.
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