Registration Dossier
Registration Dossier
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EC number: 620-097-9 | CAS number: 54299-17-1
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic / sediment
Using Bio-concentration Factor module Bio-concentration Factor of the test substance 1,4-phenylene bis[(4-phenoxyphenyl)-methanone] (CAS no. 54299 -17 -1) was estimated to be 4494347 at pH range 1-14, respectively (ACD (Advanced Chemistry Development)/I-Lab predictive module, 2017)). This value indicates that the test substance 1,4-phenylene bis[(4-phenoxyphenyl)- methanone] was considered to be very bioaccumulative in aquatic organisms.
Additional information
Bioaccumulation: aquatic / sediment
Various predicted data for the target compound 1,4-phenylene bis[(4-phenoxyphenyl)-methanone] (CAS No. 54299-17-1) and supporting weight of evidence study for its structurally similar read across substance were reviewed for the bioaccumulation end point which are summarized as below:
In a prediction done by using Bio-concentration Factor module (ACD (Advanced Chemistry Development)/I-Lab predictive module, 2017)), Bio-concentration Factor of the test substance 1,4-phenylene bis[(4-phenoxyphenyl)-methanone] (CAS no. 54299 -17 -1) was estimated to be 4494347 at pH range 1-14, respectively. This value indicates that the test substance 1,4-phenylene bis[(4-phenoxyphenyl)-methanone] was considered to be very bioaccumulative in aquatic organisms.
Another predicted data was estimated using SciFinder database (American Chemical Society (ACS), 2017) for predicting the bioconcentration factor (BCF) of test chemical 1,4-phenylene bis[(4-phenoxyphenyl)-methanone] (CAS No. 54299 -17 -1). The bioconcentration factor (BCF) of 1,4-phenylene bis[(4-phenoxyphenyl)-methanone] was estimated to be 1000000 at pH range 1-10 respectively (at 25 deg C) which exceeds the bio concentration threshold of 5000, indicating that the chemical 1,4-phenylene bis[(4-phenoxyphenyl)-methanone] is expected to very bioaccumulate in the food chain.
In a supporting weight of evidence study from authoritative database (2018) for the test item,the bioaccumulation experiment was conducted for estimating the BCF (bioaccumulation factor) value of test chemical. The bioaccumulation factor (BCF) value was calculated using a measured water solubility of 0.0179 mg/l and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 5900 dimensionless, which exceeds the bioconcentration threshold of 5000, indicating that the test chemical is considered to be very bioaccumulative in aquatic organisms.
On the basis of above results for target chemical 1,4-phenylene bis[(4-phenoxyphenyl)-methanone] (from modelling databases,2017), it can be concluded that the BCF value of test substance 1,4-phenylene bis[(4-phenoxyphenyl)-methanone] ranges from 1000000 –4494347 which exceeds the bioconcentration threshold of 5000, indicating that the chemical 1,4-phenylene bis[(4-phenoxyphenyl)-methanone] is expected to very bioaccumulate in the food chain.
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