Registration Dossier
Registration Dossier
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EC number: 222-212-4 | CAS number: 3387-41-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 439 (In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.46 (In Vitro Skin Irritation: Reconstructed Human Epidermis Model Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Thuj-4(10)-ene
- EC Number:
- 222-212-4
- EC Name:
- Thuj-4(10)-ene
- Cas Number:
- 3387-41-5
- Molecular formula:
- C10H16
- IUPAC Name:
- 4-methylidene-1-(propan-2-yl)bicyclo[3.1.0]hexane
Constituent 1
In vitro test system
- Test system:
- human skin model
- Source species:
- other: EpiDermTM tissues
- Cell type:
- non-transformed keratinocytes
- Cell source:
- other: EpiDermTM tissues were procured from MatTek In Vitro Life Science Laboratories, Brati-slava.
Test animals
- Species:
- other: EpiDermTM-Kit
Test system
- Type of coverage:
- occlusive
- Controls:
- yes, concurrent positive control
- yes, concurrent negative control
- Number of animals:
- 3
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- % tissue viability
- Value:
- > 50
- Vehicle controls validity:
- not specified
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Thuj-4(10)-ene is considered non-irritant to skin in the Reconstructed human Epidermis (RhE) Test Method.
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