Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 284-294-8 | CAS number: 84837-14-9 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Thymus mastichina, Labiatae.
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Classification based on calculation rules for mixtures of the CLP Regulation and on a weight of evidence approach.
The use of constituents appoach is within the spirit of REACH and the stated aim of the legislation to reduce animal testing where possible.
So the acute toxicity oral of this UVCB substance can be estimated using adequate toxicity data of major constituents, greater than 1% or equal to 1% in the mixture.
9 constituents were considered, representing 84.5% of the mixture. These data are summarized in the table below.
The acute toxicity oral was estimated using the following additivity formula, as recommended in the Regulation (EC) No 1272/2008 (CLP) part 3.1.3.6.2.3.:
100-(∑ Ci unkown if > 10 %) / ETA mix = ∑ (Ci / ETAi)Where,Ci = concentration of component i (weight percentage); i = the individual ingredient from 1 to n ; n = the number of ingredients ; ATEi = Acute Toxicity Estimate of ingredient i.
Test material
- Reference substance name:
- Thyme, Thymus mastichina, ext.
- EC Number:
- 284-294-8
- EC Name:
- Thyme, Thymus mastichina, ext.
- Cas Number:
- 84837-14-9
- Molecular formula:
- Not relevant for UVCB
- IUPAC Name:
- Thyme, Thymus mastichina, ext.
- Test material form:
- liquid: volatile
Constituent 1
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- approximate LD50
- Effect level:
- ca. 2 346 mg/kg bw
- Based on:
- other: calculation according to additivity formula of CLP regulation section 3.1.3.6.2.3.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- With a LD50 oral > 2000 mg/kg, the spanish marjoram oil is not classified according to CLP criteria and GHS criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
