Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 944-884-4 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Daphnia-short term toxicity study
EC50 (48hr) > 100 mg/l (nominal) - EC50 (48hr) > 2.9 mg/l (measured) - Similar Substance 06
EC50 (48 hr) >100 mg/l (nominal) - EC50 (48 hr) >5.35 mg/l (measured) - Similar Substance 05
EC50 (48hr) = 154 mg/l (nominal) - fluoride
Toxicity to aquatic algae
EC50 (72hr) > 100 mg/l (nominal) - EC50 (72hr) > 1.56 mg/l (measured) - Similar Substance 05
EC50 (72hr) > 100 mg/l (nominal) - EC50 (72hr) > 4.4 mg/l (measured) - Similar Substance 06
Additional information
The aquatic toxicity of the substance to aquatic organisms (aquatic invertebrates and algae) is evaluated by considering data on similar substances. Justification for Read Across is given in Section 13 of IUCLID.
Short-term toxicity to aquatic invertebrates
The toxic potential of the similar substances to aquatic invertebrates is evaluated after the exposure of Daphnia magna at the substance for 48 hours, according to the OECD Guideline 202. No immobility or adverse effects were observed at control or 100 mg/l (nominal). The 48 hr EC50 of the two substances were both above the highest tested nominal concentration (100 mg/l) which corresponds to 2.9 mg/l (Similar Substance 06) and 5.35 mg/l (Similar Substance 05) measured concentrations.
The fluoride toxicity potential was also reported in the literature. Leblanc G.A. reported a LD50 of 340 mg/l corresponding to sodium fluoride. Fifteen daphnids were exposed to the substance for 48 hours after which they were observed for mortality (immobilisation). A LD50 of 154 mg/l is calculated for fluoride.
Toxicity to aquatic algae and cyanobacteria
The toxic potential of the substances to aquatic algae was evaluated according to the OECD Guideline 201 after a 72 -hr exposure of Pseudokirchneriella subcapitata to the tricalcium phosphate at 0, 4, 9, 21, 45, and 100 mg/l (nominal) and to calciumhydrogen phosphate at 0.3, 1, 3.1, 9.8, 31.3, and 100 mg/l. Analytical results indicated that the test substance was sparsely soluble in water. Morphological changes of algal cells were observed including expansion, aggregation, atrophy, and decoloration at 72 hours after exposure. Based on average specific growth rate and yield:
EC50 (72hr) > 100 mg/l (nominal) - Similar Substance 05 and Similar Substance 06
EC50 (72hr) > 4.4 mg/l (measured) - Similar Substance 06
EC50 (72hr) > 1.56 mg/l (measured) - Similar Substance 05
The substance is poorly soluble in water rendering its bioavailability lower than the similar substances. It could thus be expected that the aquatic organisms will be exposed in a less extent to the substance and therefore the effect concentrations will be much higher.
JUSTIFICATION FOR CLASSIFICATION
The substance's biodegradation is not tested as the evaluation of this process is not relevant for inorganic substances. In any case for classification purposes the worst-case scenario, i.e. the substance is not-readily biodegradable is considered.
Based on Annex I: Table 4.1.0 of the CLP Regulation (EC) No.1272/2008, and considering the effect concentrations reported in the literature for the similar substances, it is concluded that the substance should not be classified for aquatic toxicity according to the CLP Regulation (EC) No.1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
