7-Cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size

Justification for type of information:

The personal protective measure may be adapted appropriately when working in closed systems or under laboratory conditions.
Regular cleaning of equipment, work area and clothing.
No open handling without using reliable equipment. One technical barrier between substance and employee resp. environment.
Restricted and controlled access for trained personnel only.
Designated washing, changing and shower facilities must be available.
Internal working procedures available to personnel covering personal hygiene, decontamination /cleaning, consideration of worst case incidents, spills, emergency, alarms, waste disposal and maintenance.
Personnel comprehensively instructed, highly trained and experienced. Regular refresher training established including appropriate record keeping.
Equipment and protective garments must either be decontaminated or properly contained for disposal before leaving the area.
Disposable protective equipment is to be decontaminated before removal (decontamination shower).
Open Handling Respiration : Full face mask (EN136)
Filter : P3 (EN143)
Eye : Yes, by face mask
Hand : Normal length chemical-mechanical-resistant gloves (EN374/EN388)
worn over disposable gloves
Glove Material : Nitrile
Breakthrough time: 240 min
Thickness: 0.4 mm
Additional protection : Disposable dust-proof suit (EN465, type 4) worn over long underwear
Disposable boot covers, conductive