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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2016-05-09 to 2016-07-28
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995-07-27
Deviations:
no
GLP compliance:
no
Type of method:
column elution method
Key result
Water solubility:
10 - 500 µg/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
6.3

The table below shows that the determination of the water solubility at a flow rate of 12.5 mL/h yielded values of 10μg/L.

At a flow rate of 6.25 mL/h no concentration plateau was reached. The determined concentrations range from 60μg/L to 180μg/L.

Flow rate

[mL/h]

Fraction

No.

Volume of

combined fractions

[ml]

Test Item

[μg/500 μL]

 

Test Item

[μg/L]

 

12.5

1 (1-2)

20

0.2

10

 

2 (3-4)

20

0.2

10

 

3 (5-6)

20

0.2

10

 

4 (7-8)

20

0.2

10

 

5 (9-10)

20

0.2

10

 

6 (11-12)

20

0.2

10

 

7 (13-14)

20

0.2

10

 

8 (15-16)

20

0.2

10

 

 

 

 

 

6.25

1 (1-2)

20

2.8

140

 

2 (3-4)

20

1.7

85

 

3 (5-6)

20

1.8

90

 

4 (7 -8)

20

1.6

80

 

5 (9-10)

20

3.6

180

 

6 (11-12)

20

1.5

75

 

7 (13-14)

20

1.2

60

 

8 (15-16)

20

1.3

65

According to OECD 105, the flow rate has to be further decreased if the values in the slower run increase. The results of this slower run are summarised in the table below:

Flow rate

[mL/h]

Fraction

No.

Volume of

combined fractions

[ml]

Test Item

[μg/500 μL]

 

Test Item

[μg/L]

 

6.25

1 (1-2)

20

2.6

130

 

2 (3-4)

20

2.9

145

 

3 (5-6)

20

2.1

105

 

4 (7-8)

20

2.2

110

 

5 (9-10)

20

1.4

70

 

6 (11-12)

20

1.1

55

 

7 (13-14)

20

1.1

55

 

8 (15-16)

20

1.0

50

 

 

 

 

 

3.125

1 (1-2)

20

8.1

405

 

2 (3-4)

20

5.4

270

 

3 (5-6)

20

3.5

175

 

4 (7-8)

20

3.6

180

 

5 (9-10)

20

2.7

135

 

6 (11-12)

20

6.5

325

 

7 (13-14)

20

6.6

330

 

8 (15-16)

20

10.0

500

lt was not possible to obtain concentration plateaus for the experiments.

Furthermore higher concentrations of the test item were observed in the slower runs and the determined concentrations show some variation within and especially between the runs.

Due to these differences the flask method was tried for the less soluble test item, too.

The determined concentrations range from 30μg/L to 244.8μg/L. However, at these low concentrations this has to be regarded as acceptable.

To allow for these uncertainties, the water solubility has to be given as the range from 10 μg/L to 500 μg/L.

The water solubility was determined at 20 °C. The pH value of the collected aqueous fractions was 6.3.

Conclusions:
The water solubility of N,N'-[(methylimino)bis(trimethylene)]bis(stearamide) is reported to be in a range from 10 μg/L to 500 μg/L at 20 °C.
Executive summary:

Water solubility of N,N'-[(methylimino)bis(trimethylene)]bis(stearamide) was determined according to OECD Guideline 105 (27 July 1995) using the column elution method.

It was not possible to obtain concentration plateaus for the experiments.

Furthermore higher concentrations of the test item were observed in the slower runs and the determined concentrations show some variation within and especially between the runs.

Due to these differences the flask method was tried for the less soluble test item, too.

The determined concentrations range from 30 μg/L to 244.8 μg/L. However, at these low concentrations this has to be regarded as acceptable.

 

To allow for these uncertainties, the water solubility has to be given as the range from 10 μg/L to 500 μg/L at 20 °C and a pH of 6.3.

Description of key information

The water solubility of N,N'-[(methylimino)bis(trimethylene)]bis(stearamide) is reported to be in a range from 10 μg/L to 500 μg/L at 20 °C.

Key value for chemical safety assessment

Water solubility:
500 µg/L
at the temperature of:
20 °C

Additional information

Water solubility of N,N'-[(methylimino)bis(trimethylene)]bis(stearamide) was determined according to OECD Guideline 105 using the column elution method.

It was not possible to obtain concentration plateaus for the experiments. Furthermore higher concentrations of the test item were observed in the slower runs and the determined concentrations show some variation within and especially between the runs.

Due to these differences the flask method was tried for the less soluble test item, too.

The determined concentrations range from 30 μg/L to 244.8 μg/L. However, at these low concentrations this has to be regarded as acceptable.

 

To allow for these uncertainties, the water solubility has to be given as the range from 10 μg/L to 500 μg/L at 20 °C and a pH of 6.3.

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