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EC number: 236-793-7 | CAS number: 13483-58-4
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016-05-09 to 2016-07-28
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995-07-27
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- column elution method
- Key result
- Water solubility:
- 10 - 500 µg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 6.3
- Conclusions:
- The water solubility of N,N'-[(methylimino)bis(trimethylene)]bis(stearamide) is reported to be in a range from 10 μg/L to 500 μg/L at 20 °C.
- Executive summary:
Water solubility of N,N'-[(methylimino)bis(trimethylene)]bis(stearamide) was determined according to OECD Guideline 105 (27 July 1995) using the column elution method.
It was not possible to obtain concentration plateaus for the experiments.
Furthermore higher concentrations of the test item were observed in the slower runs and the determined concentrations show some variation within and especially between the runs.
Due to these differences the flask method was tried for the less soluble test item, too.
The determined concentrations range from 30 μg/L to 244.8 μg/L. However, at these low concentrations this has to be regarded as acceptable.
To allow for these uncertainties, the water solubility has to be given as the range from 10 μg/L to 500 μg/L at 20 °C and a pH of 6.3.
Reference
The table below shows that the determination of the water solubility at a flow rate of 12.5 mL/h yielded values of 10μg/L.
At a flow rate of 6.25 mL/h no concentration plateau was reached. The determined concentrations range from 60μg/L to 180μg/L.
Flow rate [mL/h] |
Fraction No. |
Volume of combined fractions [ml] |
Test Item [μg/500 μL]
|
Test Item [μg/L]
|
12.5 |
1 (1-2) |
20 |
0.2 |
10 |
|
2 (3-4) |
20 |
0.2 |
10 |
|
3 (5-6) |
20 |
0.2 |
10 |
|
4 (7-8) |
20 |
0.2 |
10 |
|
5 (9-10) |
20 |
0.2 |
10 |
|
6 (11-12) |
20 |
0.2 |
10 |
|
7 (13-14) |
20 |
0.2 |
10 |
|
8 (15-16) |
20 |
0.2 |
10 |
|
|
|
|
|
6.25 |
1 (1-2) |
20 |
2.8 |
140 |
|
2 (3-4) |
20 |
1.7 |
85 |
|
3 (5-6) |
20 |
1.8 |
90 |
|
4 (7 -8) |
20 |
1.6 |
80 |
|
5 (9-10) |
20 |
3.6 |
180 |
|
6 (11-12) |
20 |
1.5 |
75 |
|
7 (13-14) |
20 |
1.2 |
60 |
|
8 (15-16) |
20 |
1.3 |
65 |
According to OECD 105, the flow rate has to be further decreased if the values in the slower run increase. The results of this slower run are summarised in the table below:
Flow rate [mL/h] |
Fraction No. |
Volume of combined fractions [ml] |
Test Item [μg/500 μL]
|
Test Item [μg/L]
|
6.25 |
1 (1-2) |
20 |
2.6 |
130 |
|
2 (3-4) |
20 |
2.9 |
145 |
|
3 (5-6) |
20 |
2.1 |
105 |
|
4 (7-8) |
20 |
2.2 |
110 |
|
5 (9-10) |
20 |
1.4 |
70 |
|
6 (11-12) |
20 |
1.1 |
55 |
|
7 (13-14) |
20 |
1.1 |
55 |
|
8 (15-16) |
20 |
1.0 |
50 |
|
|
|
|
|
3.125 |
1 (1-2) |
20 |
8.1 |
405 |
|
2 (3-4) |
20 |
5.4 |
270 |
|
3 (5-6) |
20 |
3.5 |
175 |
|
4 (7-8) |
20 |
3.6 |
180 |
|
5 (9-10) |
20 |
2.7 |
135 |
|
6 (11-12) |
20 |
6.5 |
325 |
|
7 (13-14) |
20 |
6.6 |
330 |
|
8 (15-16) |
20 |
10.0 |
500 |
lt was not possible to obtain concentration plateaus for the experiments.
Furthermore higher concentrations of the test item were observed in the slower runs and the determined concentrations show some variation within and especially between the runs.
Due to these differences the flask method was tried for the less soluble test item, too.
The determined concentrations range from 30μg/L to 244.8μg/L. However, at these low concentrations this has to be regarded as acceptable.
To allow for these uncertainties, the water solubility has to be given as the range from 10 μg/L to 500 μg/L.
The water solubility was determined at 20 °C. The pH value of the collected aqueous fractions was 6.3.
Description of key information
The water solubility of N,N'-[(methylimino)bis(trimethylene)]bis(stearamide) is reported to be in a range from 10 μg/L to 500 μg/L at 20 °C.
Key value for chemical safety assessment
- Water solubility:
- 500 µg/L
- at the temperature of:
- 20 °C
Additional information
Water solubility of N,N'-[(methylimino)bis(trimethylene)]bis(stearamide) was determined according to OECD Guideline 105 using the column elution method.
It was not possible to obtain concentration plateaus for the experiments. Furthermore higher concentrations of the test item were observed in the slower runs and the determined concentrations show some variation within and especially between the runs.
Due to these differences the flask method was tried for the less soluble test item, too.
The determined concentrations range from 30 μg/L to 244.8 μg/L. However, at these low concentrations this has to be regarded as acceptable.
To allow for these uncertainties, the water solubility has to be given as the range from 10 μg/L to 500 μg/L at 20 °C and a pH of 6.3.
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