Registration Dossier
Registration Dossier
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EC number: 270-220-1 | CAS number: 68413-48-9
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21 September 2017 to 22 February 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Specific details on test material used for the study:
- - Purity: 84%
- Description: Liquid - Details on study design: HPLC method:
- Test Substance Stock
A 10 mg/mL of test item stock solution was prepared by bringing 0.1365 g (0.1147 g as active ingredient) of the test substance to a final volume of 11.466 mL with methanol. This stock solution was stored in a refrigerator in an amber glass bottle with a Teflon-lined cap.
Test Procedure
HPLC: UV detection at 210 and 240nm.
Retention time: Approximately 39.63 to 40.60 minutes for the test item.
Column temperature: 30 °C
Mobile Phase: Purified reagent water/acetonitrile (45/55, v/v), Isocratic
Mobile Phase Flow Rate: 1.0 mL/min - Key result
- Type:
- log Koc
- Remarks:
- soil sample
- Value:
- 8.58 dimensionless
- Key result
- Type:
- log Koc
- Remarks:
- sludge sample
- Value:
- 8.67 dimensionless
- Details on results (HPLC method):
- The mean log Koc values of the test item in soil and sludge were determined by extrapolation to be 8.58 (Koc 384844937) and 8.67 (Koc 471468624), respectively.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The mean log Koc values of the test item in soil and sludge were determined by extrapolation to be 8.58 (Koc 384844937) and 8.67 (Koc 471468624), respectively.
- Executive summary:
In a study performed to the standardised guideline OECD 121, under GLP conditions, the mean log Koc values of the test item in soil and sludge were determined by extrapolation to be 8.58 (Koc 384844937) and 8.67 (Koc 471468624), respectively.
Reference
Description of key information
In a study performed to the standardised guideline OECD 121., under GLP conditions, the mean log Koc values of the test item in soil and sludge were determined by extrapolation to be 8.58 (Koc 384844937) and 8.67 (Koc 471468624), respectively.
Key value for chemical safety assessment
- Koc at 20 °C:
- 384 844 937
Additional information
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